Academic Staff and Fellows
- TSUJIUCHI Toshifumi
- Professor Doctor of Medical Science (DMSc)
- Department/Life Science Graduate school/Science
Cancer progresses in stages: as genetic abnormalities accumulate, it progresses from precancerous lesions to cancer. In addition to searching for genetic mutations of unfavorable prognoses, refractory cancer, such as in pancreatic cancer, lung cancer, and bone cancer, research includes cell function analysis through the creation of cancer cells to knock down target genes. The goal is to shed light on molecular mechanisms in cancer infiltration and metastases, and in the acquisition of resistance to anti-cancer drugs.
multi-step carcinogenesis
| Research Area | Molecular Oncology, Diagnostic Pathology, Experimental Pathology |
|---|---|
| Research Interests | Roles of lipid G-protein coupled receptors in malignant progression of cancer cells |
| Selected Publications |
(1) Effects of free fatty acid receptor-2 (FFAR2)-mediated signaling on the regulation of cellular functions in osteosarcoma cells. Biochem Biophys Res Commun. 646 (2023) 56-62. (2) Effects of lysophosphatidic acid (LPA) signaling via LPA receptors on cellular functions associated with ATP reduction in osteosarcoma cells treated with ethidium bromide. J Bioenerg Biomembr. 54 (2022) 109-117. (3) Roles of endothelial cells in the regulatio of cell motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma cells. Exp Mol Pathol 118 (2021) 104596. |
| Research and Achievements | |
| Education (Master's/Doctral Course) |
Nara Medical University Graduate School |
Molecular Oncology Laboratory
ttujiuch（at）life.kindai.ac.jp
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