Academic Staff and Fellows
- TSUJIUCHI Toshifumi
- Professor Doctor of Medical Science (DMSc)
- Department/Life Science Graduate school/Science
Cancer progresses in stages: as genetic abnormalities accumulate, it progresses from precancerous lesions to cancer. In addition to searching for genetic mutations of unfavorable prognoses, refractory cancer, such as in pancreatic cancer, lung cancer, and bone cancer, research includes cell function analysis through the creation of cancer cells to knock down target genes. The goal is to shed light on molecular mechanisms in cancer infiltration and metastases, and in the acquisition of resistance to anti-cancer drugs.
|Research Area||Molecular Oncology, Diagnostic Pathology, Experimental Pathology|
|Research Interests||Roles of lipid G-protein coupled receptors in malignant progression of cancer cells|
(1) LPA5-mediated signaling induced by endothelial cells and anticancer drug regulates cellular functions of osteosarcoma cells. Exp Cell Res. 2020, doi: 10.1016/j.yexcr.2020.111813
(2) Modulation of chemoresistance by lysophosphatidic acid (LPA) signaling through LPA5 in melanoma cells treated with anticancer drugs. Biochem Biophys Res Commun. 2019 (517) 359-363.
(3) Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells. Exp Cell Res. 2018 (369) 316-324.
|Research and Achievements|
|Nara Medical University Graduate School|
Molecular Oncology Laboratory