Researchers

YOSHIDA Koji

YOSHIDA Koji
Professor
Faculty Department of Biomedical Engineering / Graduate School of Biology-Oriented Science and Technology
Researchmap https://researchmap.jp/read0033897

Education and Career

Education

  • - 1984 , Kinki University, Faculty of Medicine,
  • - 1990 , Kinki University, Graduate School, Division of Medicine,
  • 1978/04 - 1984/03 , Kindai University, Faculty of Medicine,
  • 1986/04 - 1990/03 , Kindai University, Graduate School of Medical Sciences,

Academic & Professional Experience

  • Apr. 2015 - Today , Kindai University Faculty of Biology-Oriented Science and Technology, Department of Biomedical Engineering 教授
  • Apr. 2007 - Mar. 2015 , Kindai University Faculty of Medicine 准教授
  • Apr. 2001 - Mar. 2007 , Kindai University Faculty of Medicine 講師
  • Apr. 1990 - Mar. 2001 , Kindai University Faculty of Medicine 助手

Research Activities

Research Areas

  • Life sciences, Pathobiochemistry
  • Life sciences, Medical biochemistry
  • Life sciences, Molecular biology

Research Interests

分子生物学, 病態医化学, 生化学, Molecular Biology, Pathological Medical Chemistry, Biochemistry

Published Papers

  1. Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.
    Moe Iwai; Miniwan Tulafu; Shinsaku Togo; Hideya Kawaji; Kotaro Kadoya; Yukiko Namba; Jin Jin; Junko Watanabe; Takahiro Okabe; Moulid Hidayat; Issei Sumiyoshi; Masayoshi Itoh; Yu Koyama; Yasuhiko Ito; Akira Orimo; Kazuya Takamochi; Shiaki Oh; Kenji Suzuki; Yoshihide Hayashizaki; Koji Yoshida; Kazuhisa Takahashi
    Molecular oncology  15  (5)  , 1507-1527, May. 2021  , Refereed
  2. Glycosylated Bence Jones Protein with Poor Thermal Reactivity in Heat Coagulation Tests
    Mayumi Imoto; Katsunori Watanabe; Koji Yoshida; Ken-ichi Nakae; Toshinori Kamisako; Toshiyuki Yamada
    Clinical Laboratory  66  (11/2020)  , 2365-2369, Nov. 2020  , Refereed
  3. Inhibition by Epigallocatechin Gallate of IL-1-Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts
    Sugioka K; Yoshida K; Murakami J; Itahashi M; Mishima H; Nishida T; Kusaka S
    Invest Ophthalmol Vis Sci.  60  (8)  , 2895-2903, Jul. 2019  , Refereed

MORE

Conference Activities & Talks

  1. Epigallocatechin Gallate inhibits IL-1-Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation in Corneal Fibroblasts , 吉田 浩二; 杉岡 孝二; 髙橋 彩; 村上 純子; 三島 弘; 西田 輝夫; 日下 俊次 , 第93回日本生化学会大会 , 14, Sep. 2020
  2. ITGA11-fibronectinカスケードを介する癌関連肺線維芽細胞の遊走能の解析 , 岩井萌; 十合晋作; 川路英哉; 伊藤昌可; Miniwan Tulafu; 渡邊純子; 門屋講太郎; 難波由喜子; 鈴木健司; 折茂 彰; 吉田浩二; 林崎良英; 高橋和久 , 第60回日本肺癌学会学術集会 , 6, Dec. 2019
  3. HCEC+uPARにおける TGF-β誘導性上皮間葉転換の検討 , 木村優太; 吉田浩二; 坂田喜美; 濱野将大 , 第92回 日本生化学会大会 , 18, Sep. 2019

MORE

MISC

  1. ITGA11-fibronectinカスケードを介する癌関連肺線維芽細胞の遊走能の解析 , 岩井 萌; 十合 晋作; 川路 英哉; 伊藤 昌可; Miniwan Tulafu; 渡邊 純子; 門屋 講太郎; 難波 由喜子; 鈴木 健司; 折茂 彰; 吉田 浩二; 林崎 良英; 高橋 和久 , 肺癌 , 59 , 6 , 789 , 789 , Nov. 2019
  2. The role of the interaction between TGF-β and integrin in the eye wound healing , YOSHIDA Koji , 2011-2013科研費(基盤C, 課題番号：23592596）研究成果報告書 , Apr. 2014
    Summary:When corneal fibroblast (keratocyte) was stimulated by TGF-beta, the keratocytes showed myofibroblast-like morphology. In addition, the expression of integrin alpha11 (ITGA11), alpha-smooth muscle actin (alpha-SMA), fibronectin in keratocytes was increased by TGF-beta treatment. Sensitivity to TGF-beta was up-regulated in the cells constitutively expressing ITGA11 or calcium-and integrin-binding protein 1. It was suggested that ITGA11 and CIB1 could be the target protein of the organ fibrosis treatment. Furthermore, we found that the green tea component epigallocatechin-3-gallate (EGCG) binds to TGF-beta type II receptor and inhibits the action of TGF-beta.
  3. Roles of cytoskeletal proteins in organic fibrosis and their application of therapy in fibrotic diseases , 吉田 浩二 , 2008～2010年度 科学研究費補助金（基盤研究（Ｃ））研究成果報告書 , Mar. 2011
    Summary:transgelinをノックダウンした筋線維芽細胞は活性化が抑制された。また、TGF-βでヒト肺線維芽細胞を刺激したとき、インテグリンα11(ITGA11)の発現が著明に亢進した。calcium and integrin binding protein 1 (CIB1)はITGA11の細胞内ドメインと結合した。TGF-β処理した肺線維芽細胞およびブレオマイシンにより肺線維症を起こしたマウスの肺組織においてCIB1の発現が増加する傾向が見られたことから、CIB1が線維化に関与している可能性が示唆された。

MORE

Awards & Honors

  1. 2008, 近畿大学医学会賞
  2. 2006, 近畿大学医学会賞
  3. 2003, 近畿大学医学会賞

MORE

Research Grants & Projects

  1. 文部科学省, 科学研究費補助金（基盤研究(C)）, 緑茶カテキンEGCGを用いた臓器線維症治療のための基礎的研究
  2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Investigation of uPA/uPAR induced EMT in ARPE-19 , Kindai University
  3. Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), The role of the interaction between integrin and TGF-beta in the eye wound healing , 近畿大学

MORE