Researchers

YONESAKA Kimio

YONESAKA Kimio
Associate Professor
Faculty Department of Medicine / Graduate School of Medical Sciences
Researchmap https://researchmap.jp/mahoy

Research Activities

Research Areas

  • Life sciences, Tumor diagnostics and therapeutics

Research Interests

cancer

Published Papers

  1. Constitutive EGFR Activation Induced by PTPRR Downregulation Confers Resistance to KRAS Inhibitors.
    Hiroaki Kanemura; Toshiyuki Takehara; Osamu Maenishi; Shuta Tomida; Natsumi Iwawaki; Kei Kunimasa; Tomohiro Nakayama; Satomi Watanabe; Shinichiro Suzuki; Kazuko Sakai; Koichi Azuma; Keita Kudo; Kazuto Nishio; Kazuhiko Nakagawa; Hidetoshi Hayashi; Takeshi Teramura; Kimio Yonesaka
    Cancer research communications  6  (4)  , 728-741, 1, Apr. 2026 
  2. Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC
    Kohsuke Isomoto; Koji Haratani (co-first author and corresponding author); Takahiro Tsujikawa; Shuta Tomida; Yusuke Makutani; Masayuki Takeda; Kimio Yonesaka; Kaoru Tanaka; Tsutomu Iwasa; Kazuko Sakai; Kazuto Nishio; Akihiko Ito; Kazuhiko Nakagawa; Hidetoshi Hayashi
    Journal of Clinical Investigation  10, Mar. 2026  , Refereed
  3. Development of Second Primary Malignancies in Long-term Survivors of Unresectable Esophageal Cancer.
    Ryotaro Watanabe; Seiichiro Mitani; Masaki Okura; Chiaki Inagaki; Junko Tanizaki; Kaoru Tanaka; Tsutomu Iwasa; Kimio Yonesaka; Hidetoshi Hayashi
    Cancer diagnosis & prognosis  6  (2)  , 359-367, 2026 

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MISC

  1. PTPRRのダウンレギュレーションにより誘導されるEGFRの恒常的活性化はKRAS阻害薬耐性を付与する(Constitutive activation of EGFR induced by downregulation of PTPRR confers resistance to KRAS inhibitors) , 金村 宙昌; 竹原 俊幸; 前西 修; 冨田 秀太; 岩脇 菜摘; 國政 啓; 中山 智裕; 渡邊 諭美; 鈴木 慎一郎; 坂井 和子; 東 公一; 西尾 和人; 中川 和彦; 林 秀敏; 米阪 仁雄 , 肺癌 , 65 , 5 , 394 , 394 , Nov. 2025
  2. Chromosomal instability leads to EGFR-TKI refractoriness via cGAS-STING activation in EGFR-mutated non-small cell lung cancer , Kimio Yonesaka; Takashi Kurosaki; Junko Tanizaki; Hisato Kawakami; Kaoru Tanaka; Osamu Maenishi; Shiki Takamura; Kazuko Sakai; Yasutaka Chiba; Takeshi Teramura; Hiroki Goto; Eri Otsuka; Hiroaki Okida; Masanori Funabashi; Yuuri Hashimoto; Kenji Hirotani; Yasuki Kamai; Takashi Kagari; Kazuto Nishio; Kazuhiro Kakimi; Hidetoshi Hayashi , CANCER RESEARCH , 85 , 8 , 15, Apr. 2025
  3. ペムブロリズマブによるサイトカイン放出症候群に対して血漿交換が奏効した1例 , 宮田将行; 谷崎潤子; 大倉將生; 土肥和佳; 金村宙昌; 高濱隆幸; 田中薫; 米阪仁雄; 林秀敏 , 肺癌(Web) , 65 , 6 , 2025

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Awards & Honors

  1. 2018, 日本肺癌学会 篠井河合賞
  2. 2018, 近畿大学医学会賞
  3. 2018, 第22回日本がん分子標的治療学会 優秀演題賞

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Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of Next-Generation Cancer Immunotherapy through Comprehensive Elucidation of TMB-Independent Non-Canonical Neoantigens , Kindai University
  2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Exploring mechanism underlying resistance to kras inhibitor , Kindai University
  3. 文部科学省, 基盤研究（Ｃ）, 頭頸部癌におけるセツキシマブ治療の耐性機序の解明

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