Researchers

TOMIMOTO Naofumi

TOMIMOTO Naofumi: Research associate

Faculty	Department of Medicine
Researchmap	https://researchmap.jp/Naofumi_Tomimoto

Research Activities

Research Areas

Life sciences, Molecular biology
Life sciences, Cell biology
Life sciences, Genetics

Research Interests

Schizosaccharomyces pombe, Stress Granule, Low-complexity region, Liquid-Liquid phase separation, Signaling transduction

Published Papers

Arsenite treatment induces Hsp90 aggregatesdistinct from conventional stress granules in fission yeast.
Naofumi Tomimoto; Teruaki Takasaki; Reiko Sugiura
Microbial cell (Graz, Austria) 11 , 242-253, Jul. 2024 , Refereed
ACA-28, an anticancer compound, induces Pap1 nuclear accumulation via ROS-dependent and -independent mechanisms in fission yeast.
Teruaki Takasaki; Reo Obana; Daiki Fujiwara; Naofumi Tomimoto; Golam Iftakhar Khandakar; Ryosuke Satoh; Reiko Sugiura
microPublication biology 2023 31, Aug. 2023 , Refereed
Autophagy-related genes genetically interact with Pmk1 MAPK signaling in fission yeast.
Teruaki Takasaki; Ryosuke Utsumi; Erika Shimada; Naofumi Tomimoto; Ryosuke Satoh; Reiko Sugiura
microPublication biology 2022 4, Aug. 2022 , Refereed

亜ヒ酸ストレス条件下におけるストレス顆粒とは異なるHsp90顆粒の発見と今後 , 冨本尚史; 高崎輝恒; 杉浦麗子 , 第21回日本臨床プロテオゲノミクス学会 , 7, Jun. 2025
分裂酵母プロテインキナーゼCのストレス顆粒移行の制御機構とMAPKシグナル経路活性化の関わり , 秦しほみ; 冨本尚史; 高崎輝恒; 杉浦麗子 , 第146回日本薬理学会近畿部会 , 30, Nov. 2024
ヒ素ストレス時に形成されるストレス顆粒とは異なる顆粒構造体；Hsp90顆粒の発見 , 冨本尚史; 高崎輝恒; 杉浦麗子 , 第47回日本分子生物学会年会 , 28, Nov. 2024

Phase Separation Orchestrates Cancer Signaling: Stress Granules as a Promising Target for Cancer Therapy , Reiko Sugiura; Ryosuke Satoh; Naofumi Tomimoto; Teruaki Takasaki , Phase Separation in Living Cells , 209 , 252 , 30, Sep. 2023
Summary:Liquid–liquid phase separation (LLPS) has recently emerged as a new fundamental mechanism for the eukaryotic cellular organization via the formation of membrane-less intracellular organelles exemplified by nucleoli, P-bodies, and stress granules (SGs) (Mahboubi and Stochaj 2014; Luo et al. 2018; Molliex et al. 2015). These membrane-less condensates play important roles in various physiological and pathological processes, including regulation of gene expression, cellular stress responses, and signal transduction. Recent studies have highlighted the importance of these biomolecular condensates in tumorigenesis. Among them, SGs have attracted strong attention as a promising target for cancer treatment because of their involvement in various aspects of cancer progression, ranging from cancer formation to metastasis, as well as drug resistance. SGs regulate important cancer signaling pathways, such as mTOR and MAPK via spatial recruitment of signaling molecules thus indicating that SGs constitute signaling hubs that can rewire cancer signal transduction. Additionally, exciting discoveries in mammals as well as model organisms including yeasts have indicated that several molecules involved in cancer/proliferation signaling have been shown to upregulate SG formation. In this review, we summarize the fundamental aspects of SGs as a new paradigm for dynamic modulators of various cellular signal transduction systems and then focus on recent advances in our understanding of the role of SGs in cancer biology and its application for therapeutic strategies targeting SGs.