Researchers

TAKEUCHI Yuichi

TAKEUCHI Yuichi: Professor

Faculty	Department of Pharmacy / Graduate School of Medicine
Researchmap	https://researchmap.jp/ytake

Education and Career

Education

2001/04 - 2005/03 , Nagoya City University, Faculty of Pharmaceutical Sciences,
2005/04 - 2007/03 , Nagoya City University, Graduate School of Pharmaceutical Sciences,
2007/04 - 2010/03 , The Graduate University for Advanced Studies, School of Life Science,

Academic & Professional Experience

Apr. 2024 - Today , Hokkaido University Faculty of Pharmaceutical Sciences Visiting Professor
Apr. 2024 - Today , Kindai University Faculty of Pharmacy Department of Pharmacy Professor
Jan. 2022 - Mar. 2024 , National Institutes for Quantum and Radiological Science and Technology Visiting Research Fellow
Aug. 2021 - Mar. 2024 , Hokkaido University Faculty of Pharmaceutical Sciences Associate Professor
Apr. 2018 - Mar. 2022 , Nagoya City University Graduate School of Pharmaceutical Sciences Research Fellow
Sep. 2020 - Jul. 2021 , Osaka City University Graduate School of Medicine Specially-Appointed Lecturer
Sep. 2015 - Aug. 2020 , Hungarian Medical Universities Visiting Lecturer
Sep. 2015 - Aug. 2020 , University of Szeged Faculty of Medicine Research Assistant Professor
Jan. 2016 - Dec. 2016 , Uehara Memorial Foundation Research Fellow
Apr. 2010 - Aug. 2015 , Tokyo Women's Medical University Department of Physiology Assistant Professor
Apr. 2009 - Mar. 2010 , Japan Society for the Promotion of Science Research Fellow
Apr. 2007 - Aug. 2008 , National Institute for Physiological Sciences Research Assistant

Research Activities

Research Areas

Life sciences, Neurology
Life sciences, Psychiatry
Life sciences, Neuroscience - general
Life sciences, Physiology

Research Interests

Mental disorders, Biological markers, Simulation, Basal forebrain, Deep Brain Stimulation, Electroencephalogram, Oscillation, Real-time processing, Machine learning, Prefrontal cortex, Decision making, Limbic system, Ultrasound, Neurological disorders, Optogenetics, Epilepsy, Non-Invasive Brain Stimulation, Electrophysiology, Neural circuit, Comprehensive Brain Science Network

Published Papers

TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain
Yumi Matsushita; Kaede Yoshida; Miyuki Yoshiya; Takahiro Shimizu; Satoshi Tsukamoto; Nobuki Kudo; Yuichi Takeuchi; Makoto Higuchi; Masafumi Shimojo
Proceedings of the National Academy of Sciences 121 (50) , e2404877121-, 3, Dec. 2024 , Refereed
Closed-loop brain stimulation augments fear extinction in male rats
Rodrigo Ordoñez Sierra; Lizeth Katherine Pedraza; Lívia Barcsai; Andrea Pejin; Qun Li; Gábor Kozák; Yuichi Takeuchi; Anett J. Nagy; Magor L. Lőrincz; Orrin Devinsky; György Buzsáki; Antal Berényi
Nature Communications 14 (1) , 3972-, 5, Jul. 2023 , Refereed
Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents
Li Q; Takeuchi Y; Wang J; Gellért L; Barcsai L; Pedraza LK; Nagy AJ; Kozák G; Nakai S; Kato S; Kobayashi K; Ohsawa M; Horváth G; Kékesi G; Lőrincz ML; Devinsky O; Buzsáki G; Berényi A
Neuron 111 , 2065-2075, 5, Jul. 2023 , Refereed

てんかん研究最前線 , 吉田楓; 原巧樹; 竹内雄一 , 閉ループ制御と非侵襲的脳刺激技術による新規てんかん制御法の研究開発 , 閉ループ制御と非侵襲的脳刺激技術による新規てんかん制御法の研究開発 , 北隆館 , Apr. 2025
ブレインサイエンスレビュー２０２５ , 竹内雄一 , 時間標的脳深部刺激法による神経・精神疾患の制御法開発 , 時間標的脳深部刺激法による神経・精神疾患の制御法開発 , アドスリー , Mar. 2025
超音波ニューロモデュレーション法の研究開発 , 吉田楓; Michele Chan; Gangsheng Yang; 工藤信樹; 竹内雄一 , 日本工業出版 , 2025

神経・精神疾患の制御を目的とした新規脳刺激法の研究開発 , 竹内雄一 , 日本薬学会北陸支部特別講演会 , 9, Dec. 2024
Research and development of novel brain stimulation technologies for controlling neurological and psychiatric disorders , Yuichi Takeuchi , The NIPS Synapse Meeting 2024 , 14, Nov. 2024
Research and development of novel brain stimulation technologies for controlling neurological and psychiatric disorders , Yuichi Takeuchi , 2024 Fall International Convention of The Pharmaceutical Society of Korea , 22, Oct. 2024

韓国薬学会会議派遣報告 -2024 Fall International Convention of the Pharmaceutical Society of Korea- , 川岸裕幸; 竹内雄一 , ファルマシア , 61 , 4 , 346 , 347 , 1, Apr. 2025
転出のご挨拶 , 竹内雄一 , 芳香 , 74 , 8 , 9 , 25, Mar. 2025
Chronic social defeat causes dysregulation of systemic glucose metabolism via the cerebellar fastigial nucleus , Taiga Ishimoto; Takashi Abe; Yuko Nakamura; Tomonori Tsuyama; Kunio Kondoh; Naoto Kajitani; Kaede Yoshida; Yuichi Takeuchi; Kan X. Kato; Shucheng Xu; Maru Koduki; Momoka Ichimura; Takito Itoi; Kenta Shimba; Yoshifumi Yamaguchi; Masabumi Minami; Shinsuke Koike; Kiyoto Kasai; Jessica J Ye; Minoru Takebayashi; Kazuya Yamagata; Chitoku Toda , bioRxiv , 2025.02.18.638938 , 19, Feb. 2025
Summary:Abstract Chronic psychological stress leads to hyperglycemia through the endocrine and sympathetic nervous systems, which contributes to the development of type II diabetes mellitus (T2DM). Higher plasma corticosteroids after stress is one well-established driver of insulin resistance in peripheral tissues. However, previous studies have indicated that only a fraction of patients with depression and post-traumatic disorder (PTSD) who develop T2DM exhibit hypocortisolism, so corticosteroids do not fully explain psychological stress-induced T2DM. Here, we find that chronic social defeat stress (CSDS) in mice enhances gluconeogenesis, which is accompanied by a decrease in plasma insulin, an increase in plasma catecholamines, and a drop in plasma corticosterone levels. We further reveal that these metabolic and endocrinological changes are mediated by the activation of neurons projecting from the cerebellar fastigial nucleus (FN) to the medullary parasolitary nucleus (PSol). These neurons are crucial in shifting the body’s primary energy source from glucose to lipids. Additionally, data from patients with depression reveal correlations between the presence of cerebellar abnormalities and both worsening depressive symptoms and elevated HbA1c levels. These findings highlight a previously unappreciated role of the cerebellum in metabolic regulation and its importance as a potential therapeutic target in depression, PTSD, and similar psychological disorders.

Mar. 2024, The Physiogicial Society of Japan, Promotion Award of the Physiological Society Japan for Young Scientists
Oct. 2023, Hokkaido University Cross-Departmental Symposium, Research Encouraging Award
Oct. 2022, Hokkaido University Cross-Departmental Symposium, Research Encouragement Award

Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Identification of the mechanism of chronic pain focusing on oscillatory brain activity and its application to the development of chronic pain relief therapy , Teikyo University
Ono Pharmaceutical Foundation for Oncology, Immunology, and Neurology, Research Grant, Deletion of seizure susceptibility via transcranial deep brain stimulation , Hokkaido University
Lotte Foundation, Recovery of hedonia associated with food intake via transcranial deep brain stimulation