Researchers

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SUGISAWA Ryoichi
Research associate
Faculty Department of Medicine
Researchmap https://researchmap.jp/r_sugisawa

Education and Career

Education

  • 2007/04 - 2013/03 , Nippon Veterinary and Life science University, Faculty of Veterinary Science,
  • 2013/04 - 2017/03 , The University of Tokyo, Faculty of Medicine,

Academic & Professional Experience

  • Apr. 2023 - Today , Kindai University, Faculty of Medicine Dept. of Biochemistry Assistant Professor
  • Dec. 2017 - Mar. 2023 , Trinity College Dublin School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute Research Fellow
  • Apr. 2017 - Nov. 2017 , The University of Tokyo, Faculty of Medicine Project Assistant Professor

Research Activities

Research Areas

  • Life sciences, Pathobiochemistry
  • Life sciences, Immunology
  • Life sciences, Medical biochemistry
  • Life sciences, Veterinary medicine

Research Interests

Macrophage, Innate Immunity, Inflammation, Immunometabolism, TLR, Inflammasome, NADase, Auto immune disease, Fatty liver, Obesity, Kidney disease, Neuronal disorder, Axon degeneration, Transgenic mice models, Cat / Felis catus, AIM / CD5L, SARM1, NAD

Published Papers

  1. Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle
    Masahiko Honda; Ryota Inoue; Kuniyuki Nishiyama; Takeshi Ueda; Akiyoshi Komuro; Hisayuki Amano; Ryoichi Sugisawa; Suman Dash; Jun Shirakawa; Hitoshi Okada
    Journal of Cellular Physiology  17, Sep. 2024  , Refereed
  2. SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
    Ryoichi Sugisawa; Katharine A. Shanahan; Gavin Davis; Gavin Davey; Andrew G. Bowie
    iScience  , 109940-109940, May. 2024  , Refereed
  3. Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer
    Suman Dash; Takeshi Ueda; Akiyoshi Komuro; Masahiko Honda; Ryoichi Sugisawa; Hitoshi Okada
    Cell Death & Disease  12, Feb. 2024  , Refereed

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Conference Activities & Talks

  1. エピジェネティクス制御因子UTXの欠損は浸潤性乳がん細胞の発生と肺転移を亢進する , 古室暁義; 杉澤良一; 上田健; 岡田斉 , 第21回日本臨床プロテオゲノミクス学会 , 7, Jun. 2025
  2. SARM1のNADase活性依存的な制御を受ける分子群の探索 , 杉澤 良一; Andrew Bowie; 岡田 斉 , 第21回日本臨床プロテオゲノミクス学会 , 7, Jun. 2025
  3. The role of epigenetic regulator UTX in breast cancer invasion and lung metastasis , Akiyoshi Komuro; Ryoichi Sugisawa; Takeshi Ueda; Hitoshi Okada , 第47回 日本分子生物学会年会

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MISC

  1. SARM1 regulates pro-IL-1β expression in monocytes by an NADase-dependent mechanism , Ryoichi Sugisawa; Masahiko Honda; Suman Dash; Akiyoshi Komuro; Takeshi Ueda; Andrew Bowie; Hitoshi Okada , European Journal of Immunology , 54 , S1 , 21, Aug. 2024
  2. 乳がんの浸潤と肺転移におけるエピジェネティクス制御因子UTXの役割 , 古室暁義; 杉澤良一; 上田健; 岡田斉 , 日本分子生物学会年会プログラム・要旨集(Web) , 47th , 2024
  3. Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity , Claudia Feriotti; Joana Sa-Pessoa; Ricardo Calderón-González; Lili Gu; Brenda Morris; Ryoichi Sugisawa; Jose L. Insua; Michael Carty; Amy Dumigan; Rebecca J. Ingram; Adrien Kisenpfening; Andrew G. Bowie; José A. Bengoechea , bioRxiv , 29, Sep. 2021
    Summary:<title>SUMMARY</title>Many bacterial pathogens antagonize host defence responses by translocating effector proteins into cells. It remains an open question how those pathogens not encoding effectors counteract anti-bacterial immunity. Here, we show that <italic>Klebsiella pneumoniae</italic> hijacks the evolutionary conserved innate immune protein SARM1 to control cell intrinsic immunity. <italic>Klebsiella</italic> exploits SARM1 to regulate negatively MyD88 and TRIF-governed inflammation, and the activation of the MAP kinases ERK and JNK. SARM1 is required for <italic>Klebsiella</italic> induction of IL10 by fine-tuning the p38-type I IFN axis. SARM1 inhibits the activation of <italic>Klebsiella</italic>-induced absent in melanoma 2 inflammasome to limit IL1β production, suppressing further inflammation. <italic>Klebsiella</italic> exploits type I IFNs to induce SARM1 in a capsule and LPS O-polysaccharide-dependent manner via TLR4-TRAM-TRIF-IRF3-IFNAR1 pathway. Absence of SARM1 reduces the intracellular survival of <italic>K. pneumonaie</italic> in macrophages whereas <italic>sarm1</italic> deficient mice control the infection. Altogether, our results illustrate a hitherto unknown anti-immunology strategy deployed by a human pathogen.

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Awards & Honors

  1. Sep. 2021, EFIS (European Federation of Immunological Societies), Waived Registration Grant (for Virtual 6th European Congress of Immunology - ECI 2021)
  2. Sep. 2019, The Japanese Society of Veterinary Science, Veterinary Science Young Investigator Awards
  3. Nov. 2018, HOST-PATHOGEN COMMUNICATION, TRAVEL AWARD

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Research Grants & Projects

  1. Japan Society for the Promotion of Science(JSPS), KAKENHI, Elucidating the role of SARM1 in senescence and aging related diseases , Kinki University
  2. Osaka Kidney Foundation, 令和7年度腎疾患研究助成, Elucidation of ureteral injury and inflammation using a novel mouse model of urolithiasis and urinary tract disorders , Kindai University
  3. Kindai University, Kindai University Research Enchancement Grant, 2023 Kindai University Research Enchancement Grant , Kinki University

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