Researchers

SHIRAI Atsushi

SHIRAI Atsushi
Professor/Manager
Faculty Department of Robotics / Graduate School of System Engineering / Fundamental Technology for Next Generation Research Institute
Researchmap https://researchmap.jp/a_shirai

Education and Career

Education

  • - 1993/03 , Tohoku University, School of Engineering,
  • - 1998/03 , Graduate School of Tohoku University, School of Engineering,

Research Activities

Research Areas

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering), Fluid engineering

Research Interests

Ventricular Assist Device, 鏡療法, Numerical Analysis, Capillary, Neutrophil

Published Papers

  1. Influence on Measurement Signal by Pressure and Viscosity Changes of Fluid and Installation Condition of FBG Sensor Using Blood Flow Simulation Model
    Shouhei Koyama; Toshiyuki Hayase; Suguru Miyauchi; Atsushi Shirai; Shun Chino; Yuki Haseda; Hiroaki Ishizawa
    IEEE Sensors Journal  19  (24)  , 11946-11954, 15, Dec. 2019  , Refereed
  2. Modeling of alveolar microcirculation for passage of neutrophils
    Atsushi Shirai
    Proc. 15th international Conference on Flow Dynamics (ICFD2018)  , 638-639, Nov. 2018 
  3. Elucidation of mechanism of Fiber Bragg Grating vital sensing by Ultrasonic-Measurement-Integrated simulation: Flow analysis in ultrasound flow phantom
    Suguru Miyauchi; Toshiyuki hayase; Kosuke Inoue; Toshiyuki Ogasawara; Tatsuya Tsuboi; Atsushi Shirai; Shun Chino; Shouhei Koyama; Hiroaki Ishizawa
    Proc. 15th International Conference on Flow Dynamics (ICFD2018)  , 602-603, Nov. 2018 

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Conference Activities & Talks

  1. Development of VFG-Type Left Ventricular Assist Device (Measurement of pressure-flow rate characteristics) , 笠松諒; 畑本宗一郎; 白井敦 , 日本機械学会第33回バイオフロンティア講演会 , 18, Dec. 2022
  2. 幻肢痛低減や運動機能回復への適用を目指したWebカメラを用いる安価な改良型鏡療法 , 白井敦 , 2021年度第1回ヘルスケア・医療福祉事業化交流会 , 16, Jul. 2021
  3. Development of VFP-Type Left Ventricular Assist device (Production of tricuspid check valve and examination of pumping effect) , Hiroshi Miura; Atsushi Shirai , 日本機械学会第31回バイオフロンティア講演会 , 13, Dec. 2020

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MISC

  1. 2E25 Development of pulmonary capillary network model based on the bubble mesh method : Effects of node size on capillary lengths , YAMADA Kentaro; SHIRAI Atsushi , バイオエンジニアリング講演会講演論文集 , 2016 , 28 , "2E25 , 1"-"2E25-5" , 9, Jan. 2016
    Summary:Objective of this study is to develop a realistic pulmonary capillary network model at which capillaries form a random and fine mesh having a range of the capillary length. For this objective, the authors presented a method to generate such a mesh based on the bubble mesh method which is a mesh-generation technique for the finite element method. The presented method introduces some irregular type of circular nodes in addition to the ordinary circular nodes of the bubble mesh method to give a variety to the node radius, and the capillary network is generated by the Voronoi tessellation of the nodes. In this study, two-dimensional capillary networks were examined to generate for investigation of contributions of characteristics of the irregular nodes, variation of their radius and their concentration to the variation of the capillary length. Consequently, it was shown that the presented method generated a random network and the variation could be changed by those parameters. It was found, however, that too much wide variation of the radius of the irregular nodes declined mean capillary length due to limitation of number of surrounding nodes in packing them in the domain.
  2. F051001 Observation of Motion of Blood Cells under Inclined Centrifugal Forces , SHIRAI Atsushi , Mechanical Engineering Congress, Japan , 2015 , "F051001 , 1"-"F051001-5" , 13, Sep. 2015
    Summary:Rolling of neutrophils on vessel wall of post-capillary venules is the earliest event of a cascade of a multistep process of extravasation for the host defense. Since this rolling is considered to be a trigger to initiate the subsequent extravasation process, numerous in vitro studies have been performed on their rolling characteristics using parallel flow chambers mainly focusing on contribution of binding of adhesion molecules on neutrophils and endothelial cells to their behavior. In addition to the binding of the molecules, axially aggregated red blood cells in the vessels are thought to help the neutrophils to be marginated to the vessel wall. Though the pressing force applied to the cells on the vessel wall could enhance possibility of the bond formation of the molecules, the parallel flow camber cannot apply such a force to the cells in the experiment. In this paper, a homemade inclined centrifuge microscope system was introduced. Mechanism of the system to apply a pressing force to the cells was briefly explained. Then, some experimental results of rolling characteristics of HL-60 cell line, which is a well-known model cell of neutrophils, on various types of substrate under the pressing forces were shown.
  3. 1D43 Fundamental study of interaction between erythrocyte and endothelial cell under inclined centrifugal force : Physical explanation of interaction model , YATSUYANAGI Akira; HAYASE Toshiyuki; FUNAMOTO Kenichi; INOUE Kosuke; SHIRAI Atsushi , バイオエンジニアリング講演会講演論文集 , 2015 , 27 , 171 , 172 , 8, Jan. 2015

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Patents

  1. 連続血圧測定システム、連続血圧測定方法、連続血圧測定プログラムおよび、連続血圧測定プログラムを記録したコンピュータ読み取り可能な記録媒体 , 白井敦, 早瀬敏幸 , 特許5750805
  2. 血管固さ評価装置、血管固さ評価方法、血管固さ評価プログラムおよび血管固さ評価プログラムを記録したコンピュータ読み取り可能な記録媒体 , 白井敦, 中西勉, 松野史子, 早瀬敏幸 , 特許5751540
  3. 血流可視化診断装置 , 早瀬敏幸, 船本健一, 白井敦, 山家智之, 西條芳文 , 特許4269623

Awards & Honors

  1. Apr. 2007, (一社)日本機械学会, 日本機械学会賞(論文)
  2. Mar. 2002, (財)トーキン科学技術振興財団, (財)トーキン科学技術振興財団 第12回(平成13年度)研究奨励賞

Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Development of a pulatile VAD having a valve mimicking aortic valve , Kindai University
  2. 日本学術振興会, 平成29年度科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C), 血管内皮の表面幾何形状が好中球のローリング挙動に与える影響に関する実験的研究
  3. 日本学術振興会, 平成27年度学術研究助成基金助成金 基盤研究(B), 好中球ネットーシス上のマイクロ血栓形成メカニズム解明とARDS治療法開発

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