Researchers

SAKURAI Fuminori

SAKURAI Fuminori
Professor
Faculty Department of Pharmacy / Graduate School of Medicine
Researchmap https://researchmap.jp/read0165081

Education and Career

Education

  • - 1996 , Kyoto University, Faculty of Pharmaceutical Sciences,
  • - 2001 , Kyoto University, Graduate School of Phamacentical Sciences,
  • 1992/04 - 1996/03 , Kyoto University, Faculty of Pharmaceutical Sciences,
  • 1996/04 - 2001/03 , 京都大学大学院, 薬学研究科,

Academic & Professional Experience

  • Apr. 2024 - Today , 近畿大学薬学総合研究所 教授（兼任）
  • Apr. 2024 - Today , Kindai University Department of Pharmacy 薬物動態学研究室 教授
  • Apr. 2010 - Mar. 2024 , Osaka University Graduate School of Pharmaceutical Sciences 准教授
  • Apr. 2013 - Mar. 2017 , 大阪大学大学院薬学研究科 創薬臨床研究推進分野 核酸医薬評価学 准教授（兼任）
  • Aug. 2014 - Jul. 2016 , Ministry of Education,Culture,Sports,Science and Technology 学術調査官（兼任）
  • Apr. 2005 - Mar. 2010 , National Institutes of Biomedical Innovation, Health and Nutrition 遺伝子導入制御プロジェクト 研究員
  • Apr. 2003 - Mar. 2005 , 国立医薬品食品衛生研究所 研究官

Research Activities

Research Areas

  • Life sciences, Clinical pharmacy
  • Life sciences, Pathobiochemistry
  • Life sciences, Pharmacology

Research Interests

Gene Therapy, DDS, Biopharmaceutics, Pharmacokinetics, Gene Therapy

Published Papers

  1. Evaluation of the correlation between nuclear localization levels and genome editing efficiencies of Cas12a fused with nuclear localization signals.
    Tomohito Tsukamoto; Haruna Mizuta; Eiko Sakai; Fuminori Sakurai; Hiroyuki Mizuguchi
    Journal of pharmaceutical sciences  24, Oct. 2024 
  2. Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice
    Fuminori Sakurai; Shunsuke Iizuka; Tomohito Tsukamoto; Aoi Shiota; Kahori Shimizu; Kazuo Ohashi; Hiroyuki Mizuguchi
    Journal of Controlled Release  374  , 415-424, Oct. 2024 
  3. Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment
    Naomi Shuwari; Chieko Inoue; Ikuho Ishigami; Kentaro Jingushi; Mariko Kamiya; Shigeru Kawakami; Kazutake Tsujikawa; Masashi Tachibana; Hiroyuki Mizuguchi; Fuminori Sakurai
    Journal of Controlled Release  374  , 89-102, Oct. 2024 

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Books etc

  1. 近畿大学薬学部薬物動態学研究室の紹介 , 櫻井文教 , HAB News letter , Mar. 2025
  2. 遺伝子治療薬の臨床開発の現状 , 櫻井文教 , 情報機構 , Apr. 2024
  3. 腫瘍溶解性ウイルスによる抗腫瘍免疫の活性化とがん免疫療法との併用 , 櫻井文教; 水口裕之 , Drug delivery system , Jan. 2023

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Conference Activities & Talks

  1. 腫瘍溶解性ウイルスによる抗腫瘍効果における 細胞外小胞の役割 , 櫻井文教 , 日本薬学会第145年会 , 27, Mar. 2025
  2. 薬物性肝障害リスクと反応性代謝物アシルグルクロニドとの関連 , 川瀬 篤史; 島田 紘明; 櫻井 文教 , 日本薬学会第145年会 , 29, Mar. 2025
  3. 腫瘍溶解性ウイルスであるレオウイルス感染細胞から分泌される細胞外小胞の抗腫瘍効果 , 石神育歩; 種昻なお実; 井上智恵子; 水口裕之; 櫻井文教 , 第47回日本分子生物学会年会 , 29, Nov. 2024

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MISC

  1. レオウイルス感染がん細胞由来細胞外小胞のがん細胞に対する殺細胞効果の検討 , 櫻井文教; 井上智重子; 種昂なお実; 神宮司健太郎; 神宮司健太郎; 辻川和丈; 辻川和丈; 水口裕之; 水口裕之; 水口裕之; 水口裕之; 水口裕之 , 日本DDS学会学術集会プログラム予稿集 , 37th , 2021
  2. Sequence search for cloning and genome editing , Tetsuya Suzuki; Tomohito Tsukamoto; Eiko Sakai; Fuminori Sakurai; Hiroyuki Mizuguchi , Drug Delivery System , 35 , 3 , 255 , 259 , 2020
  3. Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A. , Keisaku Wakabayashi; Fuminori Sakurai; Ryosuke Ono; Toshiyoshi Fujiwara; Hiroyuki Mizuguchi , Anticancer research , 40 , 1 , 161 , 168 , Jan. 2020
    Summary:BACKGROUND: Arming of an oncolytic adenovirus (OAd) by inserting expression cassettes of therapeutic transgenes into the OAd genome is a promising approach to enhance the therapeutic effects of an OAd. Ideally, this approach would simultaneously promote the replication of an OAd in tumor cells and transgene product-mediated antitumor effects by expressing therapeutic transgenes. We previously demonstrated that knockdown of cullin 4A (CUL4A), which is an E3 ubiquitin ligase, significantly promoted adenovirus replication by increasing the c-JUN protein level. In addition, previous studies reported that CUL4A was highly expressed in various types of tumor, and was involved in tumor growth and metastasis. MATERIALS AND METHODS: In this study, we developed a novel OAd expressing a short-hairpin RNA (shRNA) against CUL4A (OAd-shCUL4A). RESULTS: OAd-shCUL4 mediated higher levels of cytotoxic effects on various types of human tumor cell than a conventional OAd. Higher levels of OAd genome copy numbers were found in the tumor cells for OAd-shCUL4A, compared with a conventional OAd. CONCLUSION: OAd-shCUL4A showed efficient antitumor effects by both enhancing OAd replication and inhibiting tumor cell growth.

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Awards & Honors

  1. Jul. 2018, 日本遺伝子細胞治療学会, タカラバイオ賞
  2. Mar. 2017, 大阪大学 薬友会賞（研究部門）
  3. Jul. 2016, 大阪大学, 総長奨励賞

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Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Efficient Drug Targeting by oncolytic virus-meidated tumor-specific expression of artificial receptors , Kindai University
  2. 日本学術振興会, 科学研究費助成事業, 難治性がん治療用デザイナー細菌の開発 , 長崎大学
  3. 日本学術振興会, 科学研究費助成事業 挑戦的研究(萌芽), 血管を経由する新発想での臓器の脱線維化技術の開発 , 大阪大学

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