Researchers

SAKURAI Fuminori

SAKURAI Fuminori
Professor
Faculty Department of Pharmacy / Graduate School of Medicine
Researchmap https://researchmap.jp/read0165081

Education and Career

Education

  • - 1996 , Kyoto University, Faculty of Pharmaceutical Sciences,
  • - 2001 , Kyoto University, Graduate School of Phamacentical Sciences,
  • 1992/04 - 1996/03 , Kyoto University, Faculty of Pharmaceutical Sciences,
  • 1996/04 - 2001/03 , 京都大学大学院, 薬学研究科,

Academic & Professional Experience

  • Apr. 2024 - Today , Kindai University Department of Pharmacy 薬物動態学研究室 教授
  • Apr. 2010 - Mar. 2024 , Osaka University Graduate School of Pharmaceutical Sciences 准教授
  • Apr. 2013 - Mar. 2017 , 大阪大学大学院薬学研究科 創薬臨床研究推進分野 核酸医薬評価学 准教授（兼任）
  • Aug. 2014 - Jul. 2016 , Ministry of Education,Culture,Sports,Science and Technology 学術調査官（兼任）
  • Apr. 2005 - Mar. 2010 , National Institutes of Biomedical Innovation, Health and Nutrition 遺伝子導入制御プロジェクト 研究員
  • Apr. 2003 - Mar. 2005 , 国立医薬品食品衛生研究所 研究官

Research Activities

Research Areas

  • Life sciences, Clinical pharmacy
  • Life sciences, Pathobiochemistry
  • Life sciences, Pharmacology

Research Interests

Gene Therapy, DDS, Biopharmaceutics, Pharmacokinetics, Gene Therapy

Published Papers

  1. Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose‐stimulated insulin secretion
    Kahori Shimizu; Moe Ono; Takenari Mikamoto; Yuya Urayama; Sena Yoshida; Tomomi Hase; Shotaro Michinaga; Hiroki Nakanishi; Miho Iwasaki; Tomoyuki Terada; Fuminori Sakurai; Hiroyuki Mizuguchi; Hideo Shindou; Koji Tomita; Toru Nishinaka
    The FASEB Journal  38  (2)  16, Jan. 2024 
  2. Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients
    Sena Ikemoto; Fuminori Sakurai; Sora Tokuoka; Tomoki Yamashita; Kosuke Takayama; Kazuaki Hoshi; Takahiro Okabe; Issei Sumiyoshi; Shinsaku Togo; Kazuhisa Takahashi; Masashi Tachibana; Hiroyuki Mizuguchi
    PLOS ONE  18  (10)  , e0286323-e0286323, 19, Oct. 2023 
  3. Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α
    Takuma Hotani; Kanako Nakagawa; Tomohito Tsukamoto; Hiroyuki Mizuguchi; Fuminori Sakurai
    Inflammation  24, Aug. 2023  , Refereed

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Books etc

  1. 腫瘍溶解性ウイルスによる抗腫瘍免疫の活性化とがん免疫療法との併用 , 櫻井文教; 水口裕之 , Drug delivery system , Jan. 2023
  2. アデノウイルスベクターワクチンの現状と展望 , 水口裕之; 立花雅史; 櫻井文教 , Drug delivery system , Nov. 2022
  3. ヒト35型アデノウイルスを基本骨格とした腫瘍溶解性アデノウイルスの開発 , 櫻井文教; 小野良輔; 水口裕之 , BIO Clinica , Jun. 2022

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Conference Activities & Talks

  1. Antifibrotic effects of oncolytic reovirus , Ikuho Ishigami; Hiroyuki Mizuguchi; Fuminori Sakurai , The 29th Annual Meeting of Japan Society of Gene and Cell Therapy , 13, Sep. 2023
  2. Development of a novel oncolytic adenovirus composed of human adenovirus serotype 35 , Fuminori Sakurai; Ryosuke Ono; Hiroyuki Mizuguchi , The 29th Annual Meeting of Japan Society of Gene and Cell Therapy , 11, Sep. 2023
  3. Development of a replication-incompetent adenovirus vector and oncolytic adenovirus containing microRNA-mediated post-transcriptional de-targeting system , 櫻井文教; 水口裕之 , 日本薬物動態学会第37年会 , 10, Nov. 2022

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MISC

  1. レオウイルス感染がん細胞由来細胞外小胞のがん細胞に対する殺細胞効果の検討 , 櫻井文教; 井上智重子; 種昂なお実; 神宮司健太郎; 神宮司健太郎; 辻川和丈; 辻川和丈; 水口裕之; 水口裕之; 水口裕之; 水口裕之; 水口裕之 , 日本DDS学会学術集会プログラム予稿集 , 37th , 2021
  2. Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A. , Keisaku Wakabayashi; Fuminori Sakurai; Ryosuke Ono; Toshiyoshi Fujiwara; Hiroyuki Mizuguchi , Anticancer research , 40 , 1 , 161 , 168 , Jan. 2020
    Summary:BACKGROUND: Arming of an oncolytic adenovirus (OAd) by inserting expression cassettes of therapeutic transgenes into the OAd genome is a promising approach to enhance the therapeutic effects of an OAd. Ideally, this approach would simultaneously promote the replication of an OAd in tumor cells and transgene product-mediated antitumor effects by expressing therapeutic transgenes. We previously demonstrated that knockdown of cullin 4A (CUL4A), which is an E3 ubiquitin ligase, significantly promoted adenovirus replication by increasing the c-JUN protein level. In addition, previous studies reported that CUL4A was highly expressed in various types of tumor, and was involved in tumor growth and metastasis. MATERIALS AND METHODS: In this study, we developed a novel OAd expressing a short-hairpin RNA (shRNA) against CUL4A (OAd-shCUL4A). RESULTS: OAd-shCUL4 mediated higher levels of cytotoxic effects on various types of human tumor cell than a conventional OAd. Higher levels of OAd genome copy numbers were found in the tumor cells for OAd-shCUL4A, compared with a conventional OAd. CONCLUSION: OAd-shCUL4A showed efficient antitumor effects by both enhancing OAd replication and inhibiting tumor cell growth.
  3. Type I IFN signaling induces Th17 cells capable of promoting gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector , Masahisa Hemmi; Masashi Tachibana; Natsuki Fujimoto; Masaki Shoji; Fuminori Sakurai; Kouji Kobiyama; Ken J. Ishii; Shizuo Akira; Hiroyuki Mizuguchi , CYTOKINE , 100 , 150 , 150 , Dec. 2017

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Awards & Honors

  1. Jul. 2018, 日本遺伝子細胞治療学会, タカラバイオ賞
  2. Mar. 2017, 大阪大学 薬友会賞（研究部門）
  3. Jul. 2016, 大阪大学, 総長奨励賞

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Research Grants & Projects

  1. 日本学術振興会, 科学研究費助成事業, 難治性がん治療用デザイナー細菌の開発 , 長崎大学
  2. 日本学術振興会, 科学研究費助成事業 挑戦的研究(萌芽), 血管を経由する新発想での臓器の脱線維化技術の開発 , 大阪大学
  3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, A study of drug repurposing of oncolytic virus for idiopathic pulmonary fibrosis , Osaka University

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