Researchers

NISHIO Kazuto

NISHIO Kazuto
Professor/Senior Staff/Dean
Faculty Department of Medicine / Graduate School of Medical Sciences
Researchmap https://researchmap.jp/knishio

Education and Career

Academic & Professional Experience

  • Sep. 2023 - Today , Kindai University Faculty of Medicine Department of Medicine 教授
  • 2014 - Today , Kindai University Genomic Center, Life Science Research Institute Director
  • 2006 - Sep. 2023 , Kindai University Faculty of Medicine 教授

Research Activities

Research Areas

  • Life sciences, Respiratory medicine
  • Life sciences, Tumor diagnostics and therapeutics
  • Life sciences, Pharmacology
  • Life sciences, Pharmaceuticals - health and biochemistry
  • Life sciences, Neurosurgery
  • Life sciences, Gastroenterology
  • Life sciences, Obstetrics and gynecology
  • Life sciences, Pathobiochemistry

Research Interests

抗がん剤, チロシンキナーゼ阻害剤, 分子標的薬, アポトーシス, バイオマーカー, 肺癌, 遺伝子発現解析, マイクロアレイ, CD133, 化学療法, ゲフィチニブ, 遺伝子増幅, 細胞周期制御薬, ファルネシルトランスフェラーゼ, がん抑制遺伝子, CD117, 抗腫瘍効果, EGFR, アニーリング, 遺伝子移入

Published Papers

  1. Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC
    Kohsuke Isomoto; Koji Haratani (co-first author and corresponding author); Takahiro Tsujikawa; Shuta Tomida; Yusuke Makutani; Masayuki Takeda; Kimio Yonesaka; Kaoru Tanaka; Tsutomu Iwasa; Kazuko Sakai; Kazuto Nishio; Akihiko Ito; Kazuhiko Nakagawa; Hidetoshi Hayashi
    Journal of Clinical Investigation  10, Mar. 2026  , Refereed
  2. A case of endometrioid carcinoma of the endometrium that progressed to lethal neuroendocrine carcinoma as a result of TMEM178B-BRAF fusion.
    Yoko Kashima; Hisamitu Takaya; Chiho Miyagawa; Tomoyuki Otani; Kazuko Sakai; Kazuto Nishio; Noriomi Matsumura
    International cancer conference journal  15  (1)  , 99-102, Jan. 2026 
  3. Long-term progression-free survivors ("super responders") to olaparib maintenance in recurrent ovarian cancer: a multicenter real-world study (KCOG-G2101s)
    Naho Fukuda; Tsuyoshi Takashima; Hidekatsu Nakai; Emi Yoshioka; Kimihiko Ito; Roze Taniguchi; Hiroshi Tsubamoto; Takashi Motohashi; Satoe Fujiwara; Takahiro Katsuda; Shin Nishio; Hiroaki Nagano; Ryutaro Nishikawa; Kentaro Kai; Atsushi Arakawa; Kazuko Sakai; Eiichi Morii; Kazuto Nishio; Noriomi Matsumura
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY  22, Dec. 2025 

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Books etc

  1. がんゲノム医療やさしい系統講義 , 松浦, 成昭; 櫻井, 晃洋; 石岡, 千加史; 西尾, 和人; 全国がんプロ協議会 , メディカル・サイエンス・インターナショナル , Apr. 2023
  2. liquid biopsy , Kazuto Nishio , 242-248 , 242-248 , 医学図書出版(株) , Aug. 2021
  3. Efficacy of EGFR tyrosine kinase inhibitors , Kazuto Nishio , 42-45 , 42-45 , ライフサイエンス出版(株) , 15, Jul. 2021

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Conference Activities & Talks

  1. Latest Trends in Cancer Genome Research and Future Expectations for Biomarker Studies , Kazuto Nishio , Lung Cancer Leaders‘ サロン , 7, Jun. 2025
  2. Liquid Biopsy: Detecting Cancer Through Blood — The Astonishing Response of Platelets to the Tumor Microenvironment , Kazuto Nishio , ニットーボーメディカル オンラインセミナー , 31, Jan. 2025
  3. Advancements in Personalized Medicine through Cancer Proteogenomics , Kazuto Nishio , 日本プロテオーム学会2024年大会・第20回日本臨床プロテオゲノミクス学会 合同大会 , 28, Jun. 2024

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MISC

  1. Discovery of an anticancer seed targeting cancer stem cells and analysis of its mode of action , Miyuki Matsui; Hiroaki Ikeda; Kazuko Sakai; Kazuto Nishio; Masaya Imoto; Hideaki Kakeya , MOLECULAR CANCER THERAPEUTICS , 24 , 10 , B38 , B38 , 22, Oct. 2025
  2. Chromosomal instability leads to EGFR-TKI refractoriness via cGAS-STING activation in EGFR-mutated non-small cell lung cancer , Kimio Yonesaka; Takashi Kurosaki; Junko Tanizaki; Hisato Kawakami; Kaoru Tanaka; Osamu Maenishi; Shiki Takamura; Kazuko Sakai; Yasutaka Chiba; Takeshi Teramura; Hiroki Goto; Eri Otsuka; Hiroaki Okida; Masanori Funabashi; Yuuri Hashimoto; Kenji Hirotani; Yasuki Kamai; Takashi Kagari; Kazuto Nishio; Kazuhiro Kakimi; Hidetoshi Hayashi , CANCER RESEARCH , 85 , 8 , 15, Apr. 2025
  3. Pilot Study to Evaluate the Potential of the Tumor Educated Platelets (TEP) as the Tool to Detect Minimal Residual Disease and Drug Resistance , Shuta Ohara; Kenichi Suda; Kazuko Sakai; Junko Tanaka; Takamichi Muramatsu; Chihiro Uematsu; Yasuhiro Tsutani; Kazuto Nishio; Tetsuya Mitsudomi , JOURNAL OF THORACIC ONCOLOGY , 20 , 4 , S6 , S6 , Apr. 2025

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Patents

  1. 治療法の有利性を予見する予見方法 , 西尾 和人, 藤田 至彦 , 特許第6860148号
  2. がん治療のための併用療法としてのエリブリンとＳ−１（もしくは５−ＦＵ）の使用 , Kazuto Nishio , 特許第6644479号
  3. 癌治療のための非小細胞肺癌(NSCLC)および甲状腺癌患者を選択するためのバイオマーカーとしてRET融合遺伝子を使用する方法 , 林 秀敏, 中川 和彦, 西尾 和人, 岡本 邦男, 坂井 和子, 清水 俊雄, 武田 真幸, 田中 薫

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Awards & Honors

  1. Mar. 2024, 第119回日本肺癌学会関西支部学術集会, haigan_kansai119th Best Presentation Award
  2. May. 2021, The 25th Annual Meeting of the Japanese Association for Molecular Target Therapy of Cancer, Takashi Tsuruo Award
  3. Dec. 2020, Japan Society of Clinical Proteogenomics, Japan Society of Clinical Proteogenomics Award

Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Evaluation of minimal residual disease in postoperative lung cancer using platelet RNA influenced by the tumor environment. , Kindai University
  2. 日本学術振興会, 科学研究費助成事業, 血中遊離核酸検査の質保証と技能試験の開発；精確な結果に基づくゲノム医療をめざして , 浜松医科大学
  3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Validation study of a model for estimating the primary organ of cancer of unknown primary by methylation analysis of circulating tumor DNA , Kindai University

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