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1. バックファーストテクニックによる血管縫合に適した血管縫合器の考案
   上田 吉生; 西川 侑輝; 家村 真実; 草田 朗子; 中川 由美子; 西山 都
   日本マイクロサージャリー学会学術集会プログラム・抄録集  49回  , 234-234, Dec. 2022 
2. 今後の治療薬開発に向けたケロイドモデルの作製とその意義
   西川 侑輝; 伊谷 善仁; 磯貝 典孝
   創傷  13  (4)  , 174-181, Oct. 2022 
3. マウスケロイドモデルにおけるトリアムシノロンアセトニドの治療効果
   西川 侑輝; 丹羽 淳子; 末吉 遊; 坂井 和子; 西尾 和人; 磯貝 典孝
   瘢痕・ケロイド治療ジャーナル  (16)  , 31-35, Jul. 2022 

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1. The significance of nanofiber polyglycolic acid for promoting tissue repair in a rat subcutaneous implantation model. , Yu Sueyoshi; Atsuko Niwa; Yuki Nishikawa; Noritaka Isogai , Journal of biomedical materials research. Part B, Applied biomaterials , 111 , 1 , 16 , 25 , Jan. 2023
   Summary:Among various biomaterials, we focused on nanofiber-based polyglycolic acid (PGA) fabric and examined the dynamics of cells that migrate within the non-woven fabric after implantation. The efficacy of nano-PGA as a tissue reinforcement in the process of subcutaneous tissue repair was immunohistochemically investigated. Two types of clinically available PGA non-woven sheet (nano-PGA: fiber diameter = 2.0 μm, conventional PGA: fiber diameter = 14.2 μm) were used and subcutaneously implanted in rats. Samples were collected 3 days, and 1, 2, 3, and 4 weeks after the implantation to perform histological and immunohistochemical (CD68, CD163, α-SMA, Type I collagen, CD34, MCP-1, IL-6, TNF-α, TGF-β, VEGF, IgG) examinations to assess the expression of molecules related to inflammation or tissue repair. Immunohistochemical analysis in nano-PGA revealed that the intensity and positive cells (CD68, MCP-1, IL-6, TNF-α) significantly increased which indicated an early inflammatory response. This was followed by phagocytosis of nano-PGA with foreign body giant cells and CD68+ macrophages. Finally, the number of proliferating cells (CD163, α-SMA, TGF-β) and angiogenesis (CD34, VEGF) for tissue repair promoted the formation of collagen fibers (type I collagen). Unlike nano-PGA, implantation of conventional PGA sheet resulted in a prolonged inflammatory response and was characterized by the presence of discontinuous collagen fibers with many foreign body giant cells, which did not lead to tissue repair. Nano-PGA sheets demonstrated a better tissue compatibility compared with conventional PGA by inducing early polarization to M2 phenotype macrophages, which triggered subsequent angiogenesis and tissue repair in the subcutaneous tissue.
2. 次世代の人工神経 次世代における我々の人工神経の神経再生を促進させるコンセプト , 楠原 廣久; 末吉 遊; 笠井 凉; 西川 侑輝; 磯貝 典孝 , 日本マイクロサージャリー学会学術集会プログラム・抄録集 , 46回 , 102 , 102 , Nov. 2019