Researchers

NAKAJIMA Yasufumi

NAKAJIMA Yasufumi
Professor/Senior Staff
Faculty Department of Medicine / Graduate School of Medical Sciences
Researchmap https://researchmap.jp/read0069019

Education and Career

Academic & Professional Experience

  • Mar. 2022 - Today , Kindai University 麻酔科学講座
  • Jan. 2015 - Mar. 2022 , Kansai Medical University Graduate School of Medical Science, Department of Anesthesiology
  • Apr. 1992 - Dec. 2014 , Kyoto Prefectural University of Medicine 麻酔科学教室

Research Activities

Research Areas

  • Life sciences, Anesthesiology

Research Interests

集中治療医学, 麻酔学, Environmental Physiology

Published Papers

  1. Unexpected Difficult Intubation Reveals Congenital Tracheal Stenosis in an Adult During Anesthesia Induction for Gastroesophageal Junction Cancer Surgery
    Atsuhiro Kitaura; Yumi Taniguchi; Haruyuki Yuasa; Hiroatsu Sakamoto; Shota Tsukimoto; Takashi Mino; Yasufumi Nakajima
    Cureus  9, Mar. 2025 
  2. Comparison of Postoperative Nausea and Vomiting Between Sedation with Remimazolam and Dexmedetomidine in Transcatheter Aortic Valve Replacement Patients: A Single-Center Retrospective Observational Study.
    Takashi Mino; Atsuhiro Kitaura; Hiroatsu Sakamoto; Yukari Yoshino; Shota Tsukimoto; Haruyuki Yuasa; Yasufumi Nakajima
    Journal of clinical medicine  14  (5)  5, Mar. 2025 
  3. A Case of Spinal Cord Stimulation Therapy for Lower Limb Pain Due to Conus Medullaris Syndrome.
    Yukari Yoshino; Tatsushige Iwamoto; Tomoyuki Matsumoto; Atsuhiro Kitaura; Yasufumi Nakajima
    Cureus  17  (2)  , e79469-, Feb. 2025 

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MISC

  1. 術後意識障害の鑑別に難渋した症例 , 高岡 敦; 岩元 辰篤; 坂本 悠篤; 岡本 健; 北浦 淳寛; 大田 典之; 中嶋 康文 , 日本神経麻酔集中治療学会プログラム・抄録集 , 27回 , 59 , 59 , Apr. 2023
  2. A case of cardiac rupture due to chest compression , 別府賢; 別府賢; 別府賢; 一杉正仁; 元濱啓介; 元濱啓介; 元濱啓介; 藤沢聖哉; 藤沢聖哉; 岡田奈月; 岡田奈月; 徳山裕貴; 徳山裕貴; 杉谷勇季; 杉谷勇季; 杉谷勇季; 益満茜; 益満茜; 益満茜; 笹橋望; 笹橋望; 中嶋康文 , 日本集中治療医学会学術集会(Web) , 50th , 2023
  3. Impact of Permissive Hypoxia and Hyperoxia Avoidance on Clinical Outcomes in Septic Patients Receiving Mechanical Ventilation: A Retrospective Single-Center Study , Kota Nishimoto; Takeshi Umegaki; Sayaka Ohira; Takehiro Soeda; Natsuki Anada; Takeo Uba; Tomohiro Shoji; Munenori Kusunoki; Yasufumi Nakajima; Takahiko Kamibayashi , BioMed Research International , 2021 , 2021
    Summary:Background. Septic patients often require mechanical ventilation due to respiratory dysfunction, and effective ventilatory strategies can improve survival. The effects of the combination of permissive hypoxia and hyperoxia avoidance for managing mechanically ventilated patients are unknown. This study examines these effects on outcomes in mechanically ventilated septic patients. Methods. In a retrospective before-and-after study, we examined adult septic patients (aged ≥18 years) requiring mechanical ventilation at a university hospital. On April 1, 2017, our mechanical ventilation policy changed from a conventional oxygenation target (SpO2: ≥96%) to more conservative targets with permissive hypoxia (SpO2: 88-92% or PaO2: 60 mmHg) and hyperoxia avoidance (reduced oxygenation for PaO2&gt 110 mmHg). Patients were divided into a prechange group (April 2015 to March 2017 n=83) and a postchange group (April 2017 to March 2019 n=130). Data were extracted from clinical records and insurance claims. Using a multiple logistic regression model, we examined the association of the postchange group (permissive hypoxia and hyperoxia avoidance) with intensive care unit (ICU) mortality after adjusting for variables such as Sequential Organ Failure Assessment (SOFA) score and PaO2/FiO2 ratios. Results. The postchange group did not have significantly lower adjusted ICU mortality (0.67, 0.33-1.43 P=0.31) relative to the prechange group. However, there were significant intergroup differences in mechanical ventilation duration (prechange: 11.0 days, postchange: 7.0 days P=0.01) and ICU stay (prechange: 11.0 days, postchange: 9.0 days P=0.02). Conclusions. Permissive hypoxia and hyperoxia avoidance had no significant association with reduced ICU mortality in mechanically ventilated septic patients. However, this approach was significantly associated with shorter mechanical ventilation duration and ICU stay, which can improve patient turnover and ventilator access.

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Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of the pathology concerning inflammasome associated pancytopenia in severe sepsis, and its control by microRNA. , Kindai University
  2. 日本学術振興会, 科学研究費助成事業, 播種性血管内凝固症候群の血小板減少に関与するmicroRNAと標的遺伝子の同定 , 関西医科大学
  3. 日本学術振興会, 科学研究費助成事業, 重症敗血症病態の白血球減少に関与するmicroRNAと標的遺伝子、蛋白質の同定 , 関西医科大学

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