Researchers

MAEGAWA Tomohiro

MAEGAWA Tomohiro
Professor/Manager
Faculty Department of Pharmaceutical Sciences / Graduate School of Medicine / Pharmaceutical Research and Technology Institute
Researchmap https://researchmap.jp/read0198565

Education and Career

Education

  • - 1998 , Nagoya University, Faculty of Engineering,
  • - 1998 , Nagoya University, School of Engineering,
  • - 2003 , Osaka University, Graduate School, Division of Pharmaceutical Sciences,
  • - 2003 , Osaka University, 薬学研究科,

Academic & Professional Experience

  • Apr. 2019 - Today , School of Pharmaceutical Sciences Laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences Professor
  • Apr. 2013 - Mar. 2019 , Kindai University School of Pharmaceutical Sciences Associate Professor
  • Jan. 2009 - Mar. 2013 , Osaka University Graduate School of Pharmaceutical Sciences Special-Appointed Associate Professor
  • Oct. 2007 - Dec. 2008 , Gifu Pharmaceutical University Laboratory of Medicinal Chemistry Lecturer
  • Apr. 2007 - Sep. 2007 , Gifu Pharmaceutical University Laboratory of Medicinal Chemistry Assistant Professor
  • Apr. 2003 - Mar. 2007 , Gifu Pharmaceutical University Laboratory of Medicinal Chemistry Assistant Professor

Research Activities

Research Areas

  • Life sciences, Pharmaceuticals - chemistry and drug development

Research Interests

環境調和型反応, 複素環, 有機合成化学, catalytic reaction, synthetic organic chemistry

Published Papers

  1. Concise synthetic routes for diphenylacetylene from tetrachloroethylene using Suzuki coupling reaction followed by treatment with n-butyllithium
    Yuta Fujiki; Hiyono Suzuki; Junya Kikuzawa; Keiji Nishiwaki; Norihito Kawashita; Junpei Matsuoka; Akira Nakamura; Tomohiro Maegawa; Akiko Kuwabara; Masafumi Kobayashi; Kouichi Matsumoto
    Chemistry Letters  53  (6)  1, Jun. 2024 
  2. Elemental Sulfur-Mediated Aromatic Halogenation
    Junpei Matsuoka; Yuna Yano; Yuuka Hirose; Koushi Mashiba; Nanako Sawada; Akira Nakamura; Tomohiro Maegawa
    The Journal of Organic Chemistry  89  (1)  , 770-777, 19, Dec. 2023 
  3. n-Bu4NI/H2O2-catalyzed mild conversion of hydroxamic acids to carboxylic acids
    Akira Nakamura; Jyunya Morimoto; Maho Taniguchi; Haruka Aoyama; Jiadong He; Tomohiro Maegawa
    Tetrahedron Letters  126  , 154656-154656, Aug. 2023 

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Books etc

  1. クライン有機化学問題の解き方 : 日本語版 , Klein, David R.; 伊藤, 喬 , 東京化学同人 , Mar. 2020
  2. 医薬品構造化学 : 薬の構造と薬理作用の関係を紐解く , 前川, 智弘 , 京都廣川書店 , Mar. 2017

MISC

  1. Highly Discriminative and Chemoselective Deprotection/Transformations of Acetals with the Combination of Trialkylsilyl Triflate/2,4,6-Collidine , Reiya Ohta; Nao Matsumoto; Yoshifumi Ueyama; Yuichi Kuboki; Hiroshi Aoyama; Kenichi Murai; Mitsuhiro Arisawa; Tomohiro Maegawa; Hiromichi Fujioka , Journal of Organic Chemistry , 83 , 12 , 6432 , 6443 , 15, Jun. 2018
    Summary:© 2018 American Chemical Society. Acetals are the most useful protecting groups for carbonyl functional groups. In addition to the role of protection, they can also be used as synthons of carbonyl functions. Previously, we developed a chemoselective deprotection and nucleophilic substitution of acetals from aldehydes in the presence of ketals. This article describes the highly discriminative and chemoselective transformations of acetals bearing different substitution patterns, different types of acetals, as well as mixed acetals. These reactions can achieve the transformations that cannot be attained by conventional methods, and their results strongly suggest the combination of R3SiOTf/2,4,6-collidine to promote such unprecedented phenomena.
  2. The reaction of acetal-type protective groups in combination with TMSOTf and 2,2 '-bipyridyl; mild and chemoselective deprotection and direct conversion to other protective groups , Hiromichi Fujioka; Yutaka Minamitsuji; Ozora Kubo; Kento Senami; Tomohiro Maegawa , TETRAHEDRON , 67 , 16 , 2949 , 2960 , Apr. 2011
    Summary:A mild and chemoselective deprotection method of various acetal-type protective groups, such as MOM, MEM, BOM, and SEM ethers, has been developed. The combination of TMSOTf and 2,2'-bipyridyl was very effective for the deprotection, and the reaction proceeded via the formation of pyridinium intermediates, which were hydrolyzed to the corresponding alcohols in good to high yields. The features of this method are mild (almost neutral) reaction conditions and the tolerability of acid-sensitive functional groups. This method is also applicable for the direct conversion of MOM ether to BOM or SEM ether using the appropriate alcohols instead of H2O. (C) 2011 Elsevier Ltd. All rights reserved.
  3. Palladium on charcoal-catalyzed ligand-free Stille coupling , Yuki Yabe; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki , TETRAHEDRON , 66 , 45 , 8654 , 8660 , Nov. 2010
    Summary:An efficient ligand-free Stille coupling reaction catalyzed by palladium on charcoal was developed. Tetraphenyltin was reacted with a variety of aryl halides including aryl chlorides using LiCI as an additive. The reactions of tributyl organotin compounds with aryl iodides were effectively expedited by the addition of LiF. These reactions efficiently proceeded without a phosphine or arsenic ligand and no leached palladium was detected in the reaction mixture. (C) 2010 Elsevier Ltd. All rights reserved.

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Awards & Honors

  1. Aug. 2020, Kansai Branch, The Society of Synthetic Organic Chemistry, Kansai Branch Award of The Society of Synthetic Organic Chemistry
  2. 2009, プロセス化学会, 2009JSPC優秀賞
  3. 2008, 有機合成化学協会 東海支部, 平成20年度有機合成化学協会東海支部奨励賞

Research Grants & Projects

  1. 日本学術振興会, 科学研究費助成事業, 単体硫黄を活性化剤として用いるハロゲン化反応の開発と新規ラジカル反応への展開 , 近畿大学
  2. Kobayashi Foundation, 小林財団 研究助成, Development and application of novel reactions exploiting the potential activation ability of sulfur atoms towards halogen compounds. , Kindai University
  3. 文部科学省, 科学研究費補助金(基盤研究(C)), 硫黄化合物を用いる高活性なハロゲン化反応の開発とその応用

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