Researchers

Education and Career

Education

• - 1998 , Nagoya University, Faculty of Engineering,
• - 1998 , Nagoya University, School of Engineering,
• - 2003 , Osaka University, Graduate School, Division of Pharmaceutical Sciences,
• - 2003 , Osaka University, 薬学研究科,

Academic & Professional Experience

• Apr. 2019 - Today , School of Pharmaceutical Sciences Laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences Professor
• Apr. 2013 - Mar. 2019 , Kindai University School of Pharmaceutical Sciences Associate Professor
• Jan. 2009 - Mar. 2013 , Osaka University Graduate School of Pharmaceutical Sciences Special-Appointed Associate Professor
• Oct. 2007 - Dec. 2008 , Gifu Pharmaceutical University Laboratory of Medicinal Chemistry Lecturer
• Apr. 2007 - Sep. 2007 , Gifu Pharmaceutical University Laboratory of Medicinal Chemistry Assistant Professor
• Apr. 2003 - Mar. 2007 , Gifu Pharmaceutical University Laboratory of Medicinal Chemistry Assistant Professor

Research Activities

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development

Research Interests

環境調和型反応, 複素環, 有機合成化学, catalytic reaction, synthetic organic chemistry

Published Papers

1. Elemental Sulfur-Mediated Aromatic Halogenation
   Junpei Matsuoka; Yuna Yano; Yuuka Hirose; Koushi Mashiba; Nanako Sawada; Akira Nakamura; Tomohiro Maegawa
   The Journal of Organic Chemistry  89  (1)  , 770-777, 19, Dec. 2023 
2. n-Bu4NI/H2O2-catalyzed mild conversion of hydroxamic acids to carboxylic acids
   Akira Nakamura; Jyunya Morimoto; Maho Taniguchi; Haruka Aoyama; Jiadong He; Tomohiro Maegawa
   Tetrahedron Letters  126  , 154656-154656, Aug. 2023 
3. Regioselective Synthesis of 3,4-Disubstituted Isoxazoles by Using a Chalcone-Rearrangement Strategy
   Tomohiro Maegawa; Akira Nakamura; Tohko Kine; Haruna Uenishi; Yuri Maki; Yasuhito Kase; Mayo Takagi
   Synlett  34  (11)  , 1253-1258, 6, Feb. 2023 

MORE

Books etc

1. クライン有機化学問題の解き方 : 日本語版 , Klein, David R.; 伊藤, 喬 , 東京化学同人 , Mar. 2020
2. 医薬品構造化学 : 薬の構造と薬理作用の関係を紐解く , 前川, 智弘 , 京都廣川書店 , Mar. 2017

MISC

1. Highly Discriminative and Chemoselective Deprotection/Transformations of Acetals with the Combination of Trialkylsilyl Triflate/2,4,6-Collidine , Reiya Ohta; Nao Matsumoto; Yoshifumi Ueyama; Yuichi Kuboki; Hiroshi Aoyama; Kenichi Murai; Mitsuhiro Arisawa; Tomohiro Maegawa; Hiromichi Fujioka , Journal of Organic Chemistry , 83 , 12 , 6432 , 6443 , 15, Jun. 2018
   Summary:© 2018 American Chemical Society. Acetals are the most useful protecting groups for carbonyl functional groups. In addition to the role of protection, they can also be used as synthons of carbonyl functions. Previously, we developed a chemoselective deprotection and nucleophilic substitution of acetals from aldehydes in the presence of ketals. This article describes the highly discriminative and chemoselective transformations of acetals bearing different substitution patterns, different types of acetals, as well as mixed acetals. These reactions can achieve the transformations that cannot be attained by conventional methods, and their results strongly suggest the combination of R3SiOTf/2,4,6-collidine to promote such unprecedented phenomena.
2. The reaction of acetal-type protective groups in combination with TMSOTf and 2,2 '-bipyridyl; mild and chemoselective deprotection and direct conversion to other protective groups , Hiromichi Fujioka; Yutaka Minamitsuji; Ozora Kubo; Kento Senami; Tomohiro Maegawa , TETRAHEDRON , 67 , 16 , 2949 , 2960 , Apr. 2011
   Summary:A mild and chemoselective deprotection method of various acetal-type protective groups, such as MOM, MEM, BOM, and SEM ethers, has been developed. The combination of TMSOTf and 2,2'-bipyridyl was very effective for the deprotection, and the reaction proceeded via the formation of pyridinium intermediates, which were hydrolyzed to the corresponding alcohols in good to high yields. The features of this method are mild (almost neutral) reaction conditions and the tolerability of acid-sensitive functional groups. This method is also applicable for the direct conversion of MOM ether to BOM or SEM ether using the appropriate alcohols instead of H2O. (C) 2011 Elsevier Ltd. All rights reserved.
3. The reaction of acetal-type protective groups in combination with TMSOTf and 2,2 '-bipyridyl; mild and chemoselective deprotection and direct conversion to other protective groups , Hiromichi Fujioka; Yutaka Minamitsuji; Ozora Kubo; Kento Senami; Tomohiro Maegawa , TETRAHEDRON , 67 , 16 , 2949 , 2960 , Apr. 2011
   Summary:A mild and chemoselective deprotection method of various acetal-type protective groups, such as MOM, MEM, BOM, and SEM ethers, has been developed. The combination of TMSOTf and 2,2'-bipyridyl was very effective for the deprotection, and the reaction proceeded via the formation of pyridinium intermediates, which were hydrolyzed to the corresponding alcohols in good to high yields. The features of this method are mild (almost neutral) reaction conditions and the tolerability of acid-sensitive functional groups. This method is also applicable for the direct conversion of MOM ether to BOM or SEM ether using the appropriate alcohols instead of H2O. (C) 2011 Elsevier Ltd. All rights reserved.

MORE

Awards & Honors

1. Aug. 2020, Kansai Branch, The Society of Synthetic Organic Chemistry, Kansai Branch Award of The Society of Synthetic Organic Chemistry
2. 2009, プロセス化学会, 2009JSPC優秀賞
3. 2008, 有機合成化学協会 東海支部, 平成20年度有機合成化学協会東海支部奨励賞

Research Grants & Projects

1. 文部科学省, 科学研究費補助金(基盤研究(C)), 硫黄化合物を用いる高活性なハロゲン化反応の開発とその応用
2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of novel reactivitity of methylene acetals and its application to synthesis of heterocycles , Kindai University
3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of a divergent synthesis of 4- and 5-membered heterocycles and its application to the synthesis of bioactive natural product , 大阪大学

MORE