Researchers

KUWAHARA Kazuhiko

KUWAHARA Kazuhiko
Associate Professor
Faculty Department of Medicine
Researchmap https://researchmap.jp/read0068817

Education and Career

Education

  • 1983/04 - 1989/03 , Saga Medical School, 医学部,
  • 1990/04 - 1994/03 , Saga Medical School, 大学院医学研究科,

Academic & Professional Experience

  • Apr. 2025 - Today , Kindai University Faculty of Medicine Department of Pathology 准教授
  • Apr. 2022 - Today , Kindai University Department of Diagnostic Pathology, Kindai University Hospital 講師
  • Apr. 2021 - Mar. 2022 , Fujita Health University School of Medicine Department of Diagnostic Pathology 講師
  • Apr. 2018 - Mar. 2021 , Fujita Health University School of Medicine Department of Diagnostic Pathology Assistant Professor
  • Aug. 2016 - Mar. 2018 , Niigata University Graduate School of Medical and Dental Sciences 助教、講師
  • Feb. 2016 - Jul. 2016 , Hirosaki University University Hospital 医員
  • Apr. 2014 - Jan. 2016 , Aichi Cancer Center, Research Institute 腫瘍免疫学部 室長
  • Apr. 1999 - Mar. 2014 , Kumamoto University, Faculty of Life Sciences, Department of Immunology Associate Professor
  • Dec. 2001 - Mar. 2005 , 科学技術振興機構 さきがけ研究21 「認識と形成」領域 兼任研究者
  • Jan. 1996 - Dec. 1998 , 日本学術振興会 特別研究員(PD)
  • Apr. 1994 - Dec. 1995 , Tottori University School of Life Sciences, Faculty of Medicine 助手
  • Jun. 1989 - Mar. 1990 , 佐賀医科大学 医学部附属病院 外科学 研修医

Research Activities

Research Areas

  • Life sciences, Human pathology

Research Interests

抗体医薬, 転写共役型DNA傷害, 乳癌

Published Papers

  1. Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex—Lessons from Transcription-Coupled DNA Damages
    Andri Rezano; Naomi Gondo; Yasuhiro Sakai; Yuko Nakamura; Suchada Phimsen; Tokio Tani; Akihiko Ito; Seiji Okada; Kazuhiko Kuwahara
    International Journal of Molecular Sciences  19, Dec. 2024 
  2. Rare finding of mucorales sporangia and chlamydospores in tissue
    Misa Kojima; Masatomo Kimura; Kazuhiko Kuwahara; Hisatomo Tamaki; Ryuji Yasumatsu; Sota Sadamoto; Takayuki Shinohara; Kazuki Amemiya; Yoshitsugu Miyazaki; Akihiko Ito
    Pathology International  Nov. 2024 
  3. Carcinogenesis caused by transcription‐coupled DNA damage through GANP and other components of the TREX‐2 complex
    Yasuhiro Sakai; Kazuhiko Kuwahara
    Pathology International  Mar. 2024 

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Conference Activities & Talks

  1. The role of mammalian TREX2 complex in sporadic breast cancers. , Kazuhiko Kuwahara , The 3rd Bandung International Biomolecular Medicine Conference (BIBMC) , 2014
  2. DNA傷害の新たな視点 -mRNA輸送分子GANP欠損による転写共役型DNA損傷と発癌の実証- , 桑原 一彦 , 佐賀大学分子生命科学セミナー , 2012
  3. New Insights of transcription-coupled DNA damage in cell development and differentiation. , Kazuhiko Kuwahara , Special seminar in Department of Biochemistry, Faculty of Medicine, Khon Kaen University , 2011

MISC

  1. Molecular epidemiological studies of germinal center-associated nuclear protein (ganp) in the development of human sporadic breast cancers , Kazuhiko Kuwahara; Hidemi Ito; Kiyotaka Kuzushima; Hiroji Iwata; Hideo Tanaka; Keitaro Matsuo , CANCER RESEARCH , 76 , Jul. 2016
  2. DSS1 as potential prognostic marker for breast cancer progression and relapse-free patient survival , Andri Rezano; Kazuhiko Kuwahara; Mutsuko Yamamoto-Ibusuki; Masahiro Kitabatake; Penpak Moolthiya; Suchada Phimsen; Taiji Suda; Shigenobu Tone; Yutaka Yamamoto; Hirotaka Iwase; Nobuo Sakaguchi , INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE , 34 , S114 , S114 , 2014
  3. HIV-1 gp120/CD4&CXCR4膜融合複合体エピトープと感染阻止効果 , 戸田 哲平; 桑原 一彦; 近藤 直幸; 前田 洋助; 松田 善衛; 阪口 薫雄 , 日本エイズ学会誌 , 13 , 4 , 342 , 342 , Nov. 2011

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Patents

  1. 胆管がん特異的糖鎖エピトープを認識するモノクローナル抗体 , 阪口薫雄, 桑原一彦, 荒木令江, 坂本珠美
  2. GANP蛋白質 , 阪口薫雄, 桑原一彦
  3. 高病原性トリインフルエンザに対する抗体 , 阪口薫雄, 桑原一彦, 小原道法, 芝崎太

Awards & Honors

  1. Nov. 2022, 日本病理学会, 学術研究賞演説(A演説)
  2. Oct. 2018, 藤田学園医学会, 産学連携推進センター長賞
  3. 2015, 愛知健康増進財団, 医学研究・健康増進活動等研究助成金

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Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), A novel strategy by PARP inhibitors for sporadic breast cancers , Fujita Health University
  2. 日本学術振興会, 科学研究費助成事業 挑戦的萌芽研究, TREX2複合体機能不全の誘導は抗がん剤感受性亢進の標的になるのか
  3. 日本学術振興会, 科学研究費助成事業 基盤研究(C), 非遺伝性散発性乳癌の発症、悪性進展におけるTREX2複合体因子の機能解析

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