Researchers

KAWASAKI Naohito

KAWASAKI Naohito: Professor/Dean

Faculty	Department of Pharmacy / Graduate School of Medicine / Pharmaceutical Research and Technology Institute
Researchmap	https://researchmap.jp/read0181522

Education and Career

Academic & Professional Experience

2010 - Today , Kindai University Faculty of Pharmacy 教授
2007 - 2010 , Kindai University Faculty of Pharmacy 准教授
2002 - 2007 , Kindai University Faculty of Pharmacy 講師
1998 - 2002 , Kindai University Faculty of Pharmacy 助手

Research Activities

Research Areas

Environmental science/Agricultural science, Environmental load reduction/restoration technology
Environmental science/Agricultural science, Recycling systems and society
Environmental science/Agricultural science, Environmental impact assessment
Life sciences, Hygiene and public health (laboratory)

Research Interests

Toxicology, 疫学, Environmetal hygine, Water Purification, Surface Modification, Air Pollution

Published Papers

Portable and Rapid Smartphone-Based Colorimetric Assay of Peracetic Acid for Point-of-Use Medical/Pharmaceutical Disinfectant Preparation
Suphakorn Katib; Sutasinee Apichai; Jutamas Jiaranaikulwanitch; Busaban Sirithunyalug; Fumihiko Ogata; Naohito Kawasaki; Kate Grudpan; Chalermpong Saenjum
Molecules Jun. 2025
Design of Tranilast-Loaded Cation-Type Contact Lens for Sustainable Ocular Drug Delivery.
Toru Matsunaga; Ryotaro Kuwamura; Shiori Hino; Fumihiko Ogata; Hiroko Otake; Naohito Kawasaki; Shinichiro Kobayakawa; Noriaki Nagai
Pharmaceutics 17 (6) 28, May. 2025
Pharmacological Behavior of Propylene Glycol/Polyvinyl Alcohol Hydrogel Incorporating Indomethacin Nanocrystals in the Skin
Hiroko Otake; Fumihiko Ogata; Yosuke Nakazawa; Manju Misra; Masanobu Tsubaki; Naohito Kawasaki; Noriaki Nagai
Gels 11 (4) , 251-251, 27, Mar. 2025

必携・衛生試験法 , 日本薬学会 , 金原出版 , Mar. 2022
衛生試験法註解 , 日本薬学会 , 金原出版 , Oct. 2020
薬学領域の食品衛生化学 , 長澤, 一樹; 川﨑, 直人; 甲斐, 久博; 田村, 悦臣; 長岡, 寛明; 渡辺, 渡 , 廣川書店 , Mar. 2020

琵琶湖における造粒ベーマイトを用いたリン酸吸着能 , 緒方文彦; 冨永壽人; 藪谷仁志; 川﨑直人; 樺山峰明; 和田桂子 , Mar. 2011
大学生の肥満と朝食欠食およびやせ志向との関連性に関する研究 , 川﨑直人; 緒方文彦; 冨永壽人; 木下充弘; 掛樋一晃; 佐川和則 , Mar. 2011
大学生の朝食欠食と体格誤認に関する実態調査 , 冨永壽人; 緒方文彦; 掛樋一晃; 木下充弘; 川﨑直人; 佐川和則 , Mar. 2011

Study on cell type-specific cytotoxicity and its mechanism of expression induced by copper phenanthroline complexes , NAKAMURA Takehiro; KOIZUMI Oozora; OGUSHI Shoko; KIMURA Tomoki; OGATA Fumihiko; KAWASAKI Naohito , Annual Meeting of the Japanese Society of Toxicology , 51.1 , O-39 , 2024
Summary:Organometallic complexes are widely known as catalyst reagents in chemical synthesis, and their unique reactions are increasingly being recognized for their potential utility in biomedicine. However, the toxicity of these complexes cannot be adequately predicted or understood solely through conventional toxicology studies, and systematic elucidation remains elusive. Therefore, it is considered crucial in this field to discover numerous cases that allow for the comparison of toxic properties of these complexes. We have identified a copper complex, Cu-2,9-dimethyl-1,10-phenanthroline (hereafter Cu-DMP), which exhibits cytotoxicity accompanied by cellular accumulation despite both its ligands, organic compounds, and the inorganic metal being non-toxic. This study aims to analyze the cytotoxic properties of Cu-DMP and gain insights that contribute to a systematic understanding. Two murine-derived and three human-derived cell lines were used. Cells at confluency were treated with Cu-DMP, and cellular cytotoxicity was evaluated by LDH release assay. Cellular metal accumulation was measured using ICP-MS, and protein expression was assessed using western blot. In all cell types tested, copper and the ligand DMP showed minimal toxicity individually, whereas Cu-DMP exhibited strong cytotoxicity, indicating its toxic effects regardless of cell type. However, cases where toxicity did not correlate with cellular accumulation were observed. Mechanisms underlying strong cytotoxicity without cellular accumulation are currently being investigated, focusing on variations in signaling molecules associated with cell death.
Fundamental study on removal of cadmium using bagasse from aquatic environments , YAMASHIRO Kaito; MIYAMOTO Ryo; OGATA Fumihiko; FUJIWARA Yasuyuki; KAWASAKI Naohito , Annual Meeting of the Japanese Society of Toxicology , 51.1 , P-52E , 2024
Summary:Introduction: Cadmium (Cd) has been reported to accumulate in paddy fields, and there is concern about its toxicity. Bagasse (BG), which is a by-product of sugar production, has been utilized as an adsorbent for heavy metals due to its large specific surface area (SSA). Therefore, the treatment method of BG suitable for Cd removal and the detailed mechanism of adsorption were investigated. Methods: BG was calcined in the temperature range of 200‒1000°C. BG was added to a Cd solution and shaken for 24 h under multiple conditions. The equilibrium Cd concentration was measured using inductively coupled plasma–optical emission spectroscopy. The SSA, pore volume, and pHpzc (pH of the point of zero charge) were measured. Results and discussion: The pHpzc of the BGs ranged from 4.27‒6.51, suggesting that the BG surface may be negatively charged at conditions above these pH values. The amount adsorbed was higher at pH 4‒8 than at the pH 2 and 10. These results indicate that the negative charge on the BG surface and the presence of Cd(Ⅱ) cations are important for adsorption. The amount adsorbed and the SSA of BG increased with increasing calcination temperature and were the highest in BG calcined at 800°C. The amount of adsorbed was significantly associated with the SSA (r=0.837, p=0.038), mesopores (r=0.841, p=0.036), and pHpzc (r=0.818, p=0.046). These results suggest that the Cd adsorption is related to SSA, the negative charge on the BG surface, and the presence of Cd(Ⅱ) cations, and that BG calcined at 800ºC is suitable for Cd adsorption.
Synthesis and characterization of the magnetic-adsorbents from waste sugar cane and assessment of its adsorption capability of cesium ions , OGATA Fumihiko; SAKAMOTO Shou; UEMATSU Yugo; KAWASAKI Naohito , Annual Meeting of the Japanese Society of Toxicology , 51.1 , P-160 , 2024
Summary:In 2011, the Fukushima Daiichi Nuclear Power Plant accident occurred, and cesium nuclides were released into water environment. This accident causes various severs, including thyroid cancer. Thus, this work synthesized the magnetic-adsorbents (SC200F, SC400F, and SC600F) from waste sugar cane (SC) for removal of cesium ions from water environment. Physicochemical properties such as scanning electron microscope image, specific surface area, and pHpzc were evaluated and cesium ions' adsorption capability was also assessed. Consequently, the specific surface area of prepared SC samples was greater than that of virgin SC. Additionally, the value of point of zero charge (pHpzc) of SC600F (7.5) was higher than that of other adsorbents under our experimental conditions. Next, the amount of cesium ions adsorbed were in the following order: SC (0 mg/g) < SC200F (2.0 mg/g) < SC600F (6.0 mg/g) < SC400F (9.7 mg/g). Moreover, the solid-liquid separation ability of the prepared adsorbent after adsorption was evaluated. The results showed that SC400F was able to be easily separate from the sample solution with the action of the magnetic field under our experimental conditions. Finally, suggested treatment in this study significantly contributes to the development of recycling technology of biomass waste and/or purification of wastewater containing cesium ions.

粒子状リン吸着材およびその製造方法 , 川﨑直人, 緒方文彦, 戸田徳, 大谷昌司

Awards & Honors

Jun. 2022, 日本水環境学会, 日本水環境学会功労賞
Jun. 2020, The Pharmaceutical Society of Japan, The Most Published Author Award 2016-2020 Chemical and Pharmaceutical Bulletin
Sep. 2018, 日本薬学会, 日本薬学会環境・衛生部会学術賞