Researchers

IIDA Kei

IIDA Kei
Lecturer
Faculty Department of Life Science / Graduate School of Science and Engineering
Researchmap https://researchmap.jp/read0118609

Education and Career

Academic & Professional Experience

  • Apr. 2024 - Today , Kyoto University Center for Cancer Immunotherapy and Immunobiology（CCII） 特定准教授（クロスアポイントメント）
  • Apr. 2022 - Today , Kyoto University Graduate School of Medicine Visiting Researcher
  • Apr. 2022 - Today , Kindai University Faculty of Science and Engineering Lecturer
  • Jun. 2022 - Mar. 2024 , 京都大学 iPS細胞研究所 研究員(非常勤)
  • Sep. 2012 - Mar. 2022 , Kyoto University Graduate School of Medicine Research Assistant Professor
  • Dec. 2008 - Aug. 2012 , RIKEN BASE
  • Apr. 2007 - Nov. 2008 , University of California, Riverside
  • Apr. 2004 - Mar. 2007 , Nagahama Institute of Bio-Science and Technology Faculty of Bio-Science
  • Apr. 2002 - Mar. 2004 , 理化学研究所 ゲノム科学研究センター

Research Activities

Research Areas

  • Life sciences, Systems genomics

Research Interests

Cancer immunology, ALS, sinlge cell RNA-seq, RNA結合タンパク質, エピトランスクリプトーム, transcriptome, 選択的スプライシング, 情報生物学

Published Papers

  1. Invention of an oral medication for cardiac Fabry disease caused by RNA mis-splicing
    Tomonari Awaya; Teruo Sawada; Megumu Saito; Masatoshi Hagiwara; Masahiko Ajiro; Kei IIDA; Hiroko Kobayashi; Kentoku Gotanda; Toshiharu Noji; Naohiro Takemoto; Dau-Ming Niu
    Science Advances  9, Apr. 2025 
  2. Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection
    Kei Iida; Masahiko Ajiro; Akiko Nakano-Kobayashi; Yukiko Muramoto; Toru Takenaga; Masatsugu Denawa; Ryo Kurosawa; Takeshi Noda; Masatoshi Hagiwara
    BMC Biology  3, Mar. 2025 
  3. Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches
    Misa Minegishi; Takahiro Kuchimaru; Kaori Nishikawa; Takayuki Isagawa; Satoshi Iwano; Kei Iida; Hiromasa Hara; Shizuka Miura; Marika Sato; Shigeaki Watanabe; Akifumi Shiomi; Yo Mabuchi; Hiroshi Hamana; Hiroyuki Kishi; Tatsuyuki Sato; Daigo Sawaki; Shigeru Sato; Yutaka Hanazono; Atsushi Suzuki; Takahide Kohro; Tetsuya Kadonosono; Tomomi Shimogori; Atsushi Miyawaki; Norihiko Takeda; Hirofumi Shintaku; Shinae Kizaka-Kondoh; Satoshi Nishimura
    Nature Communications  14  (1)  5, Dec. 2023 

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MISC

  1. Author Correction: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. , Masahiko Ajiro; Tomonari Awaya; Young Jin Kim; Kei Iida; Masatsugu Denawa; Nobuo Tanaka; Ryo Kurosawa; Shingo Matsushima; Saiko Shibata; Tetsunori Sakamoto; Lorenz Studer; Adrian R Krainer; Masatoshi Hagiwara , Nature communications , 12 , 1 , 6039 , 6039 , 12, Oct. 2021
  2. Dicer切断反応産物の次世代シークエンス解析を利用した低分子化合物の標的RNA配列モチーフの網羅的探索 , 村田亜沙子; 高島裕介; 飯田慶; 須貝亜矢子; 萩原正敏; 中谷和彦 , 日本分子生物学会年会プログラム・要旨集(Web) , 43rd , 2020
  3. Monitoring transcriptomic changes in soil-grown roots and shoots of Arabidopsis thaliana subjected to a progressive drought stress , Khurram Bashir; Sultana Rasheed; Akihiro Matsui; Kei Iida; Maho Tanaka; Motoaki Seki , Methods in Molecular Biology , 1761 , 223 , 230 , 2018
    Summary:Numerous experiments have been performed in Arabidopsis to monitor changes in gene expression that occur in response to a variety of abiotic and biotic stresses, different growth conditions, and at various developmental stages. In addition, gene expression patterns have also been characterized among wild-type and mutant genotypes. Despite these numerous reports, transcriptional changes occurring in roots of soil-grown plants subjected to a progressive drought stress have remained undocumented. To fill this gap, we established a system that allows one to establish water-deficit conditions and to collect root and shoot samples with minimal damage to the root system. Arabidopsis plants are grown in a ceramic-based granular soil and subjected to progressive drought stress by withholding water. Root and shoot samples were collected separately, RNA was purified, and a microarray analysis of drought-stressed roots and shoots was performed at 0, 1, 3, 5, 7, and 9 days after the onset of drought stress treatment. Here, we describe the detailed protocol used to analyze the transcriptomic changes occurring in roots and shoots of soil-grown Arabidopsis subjected to a progressive drought stress.

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Research Grants & Projects

  1. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Construction of in vitro human liver disease model capable of real-time temperature mapping and its application to elucidation of disease mechanisms , Kyoto University of Advanced Science
  2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Mechanisms of supporting cell reprogramming for inducing hair cell regeneration in chick basilar papillae , Kyoto University
  3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of splicing-code with RNA-specialized machine learning system toward overcoming hereditary diseases having splicing misregulations , Kyoto University

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