Researchers
- IHARA Makoto
- Associate Professor
Faculty | Department of Applied Biological Chemistry / Graduate School of Agriculture |
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Researchmap | https://researchmap.jp/makoto.ihara |
Education and Career
Education
- - 2005/03 , Kindai University, Graduate School of Agriculture,
Academic & Professional Experience
- Apr. 2018 - Today , Kindai University Fuculty of agriculture Associate professor
- Apr. 2013 - Mar. 2018 , Kinki University Faculty of Agriculture Lecturer
- Dec. 2012 - Mar. 2018 , RIKEN SPring-8 Center Visiting Scientist
- Dec. 2012 - Mar. 2013 , Okayama University, Graduate school of medicine, dentistry and pharmaceutical sciences Assistant Professor
- Oct. 2006 - Nov. 2012 , RIKEN
- Apr. 2005 - Sep. 2006 , 近畿大学 研究員
Research Activities
Research Areas
- Life sciences, Bioorganic chemistry
- Life sciences, Functional biochemistry
- Life sciences, Structural biochemistry
- Nanotechnology/Materials, Molecular biochemistry
Research Interests
Bioorganic chemistry, Pesticide science, 構造生理学, Structural Biology
Published Papers
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Creating Pyrethrin Mimetic Phosphonates as Chemical Genetics Tools Targeting the GDSL Esterase/Lipase TcGLIP to Investigate Pyrethrin Biosynthesis
Noritada Matsuo; Yukimi Sugisaka; Shiori Aoyama; Makoto Ihara; Harue Shinoyama; Munetaka Hosokawa; Yoshinobu Kamakura; Daisuke Tanaka; Yoo Tanabe; Kazuhiko Matsuda
Journal of Medicinal Chemistry 66 (12) , 7959-7968, 13, Jun. 2023 -
Determinants of subtype-selectivity of the anthelmintic paraherquamide A on Caenorhabditis elegans nicotinic acetylcholine receptors.
Wataru Koizumi; Shuya Otsubo; Shogo Furutani; Kunihiro Niki; Koichi Takayama; Shota Fujimura; Takanobu Maekawa; Ryosuke Koyari; Makoto Ihara; Kenji Kai; Hideo Hayashi; Mohammad Shaokat Ali; Eriko Kage-Nakadai; David B Sattelle; Kazuhiko Matsuda
Molecular pharmacology 22, Mar. 2023 -
Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids.
Yuma Komori; Koichi Takayama; Naoki Okamoto; Masaki Kamiya; Wataru Koizumi; Makoto Ihara; Daitaro Misawa; Kotaro Kamiya; Yuto Yoshinari; Kazuki Seike; Shu Kondo; Hiromu Tanimoto; Ryusuke Niwa; David B Sattelle; Kazuhiko Matsuda
PLoS genetics 19 (2) , e1010522-, Feb. 2023
Conference Activities & Talks
- Actions of clothianidin and related neonicotinoids on recombinant and native nicotinic acetylcholine receptors. , Makoto Ihara , XXII International Congress of Entomology, Brisbane, Australia , 2004
- Structure activity relationship of clothianinidin and its related compounds , Makoto Ihara , The third Pan-Pacific Conference on Pesticide Science, Hawaii, USA. , 2003
- Variations in agonist and antagonist profiles for neonicotinoids on recombinant nicotinic acetylcholine receptors expressed in Xenopus oocytes , Makoto Ihara , 10th IUPAC International Congress on the Chemistry of Crop Protection, Basel, Switzerland. , 2002
MISC
- ピレスリン生合成に関わる TcGLIP の機能および構造の解明(3)−阻害活性と阻害の様式− , 竹内孝幸; 明石拓也; 宇都宮麻衣; 伊原 誠; 平竹 潤; 松田一彦 , 日本農芸化学会2015年度大会 , Mar. 2015
- ピレスリン生合成に関わる TcGLIP の機能および構造の解明(2)−ホスホン酸型反応機構依存的阻害剤の設計と合成− , 明石拓也; 竹内孝幸; 宇都宮麻衣; 伊原 誠; 松田一彦; 平竹 潤 , 日本農芸化学会2015年度大会 , Mar. 2015
- Exon 3 Splicing and Mutagenesis Identify Residues Influencing Cell Surface Density of Heterologously Expressed Silkworm (Bombyx mori) Glutamate-Gated Chloride Channels (vol 86, pg 686, 2014) , S. Furutani; M. Ihara; Y. Nishino; M. Akamatsu; A. K. Jones; D. B. Sattelle; K. Matsuda , MOLECULAR PHARMACOLOGY , 87 , 1 , 141 , 141 , Jan. 2015
Awards & Honors
- Mar. 2018, 日本農芸化学会, 農芸化学奨励賞
- 2008, 日本農学進歩賞
- 2007, 望月喜多司記念賞 奨励賞
Research Grants & Projects
- 日本学術振興会, 科学研究費助成事業 基盤研究(B), 選択的害虫防除に向けた種選択能を有したニコチン性受容体標的薬剤設計の分子基盤研究 , 近畿大学
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Elucidation of the molecular determinants of neonicotinoid toxicity , Kindai University
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Elucidation of molecular mechanism of pyrethrin biosynthesis by a GDSL lipase and its application to creation of insect resistant plants , Kinki University