Researchers
- IHARA Makoto
- Professor
| Faculty | Department of Applied Biological Chemistry / Graduate School of Agriculture |
|---|---|
| Researchmap | https://researchmap.jp/makoto.ihara |
Education and Career
Academic & Professional Experience
- Apr. 2025 - Today , Kindai University Faculty of Agriculture, Department of Applied Biological Chemistry Professor
- Apr. 2018 - Mar. 2025 , Kindai University Fuculty of agriculture Associate professor
- Apr. 2013 - Mar. 2018 , Kinki University Faculty of Agriculture Lecturer
- Dec. 2012 - Mar. 2018 , RIKEN SPring-8 Center Visiting Scientist
- Dec. 2012 - Mar. 2013 , Okayama University, Graduate school of medicine, dentistry and pharmaceutical sciences Assistant Professor
- Oct. 2006 - Nov. 2012 , RIKEN
- Apr. 2005 - Sep. 2006 , 近畿大学 研究員
Research Activities
Research Areas
- Life sciences, Bioorganic chemistry
- Life sciences, Functional biochemistry
- Life sciences, Structural biochemistry
- Nanotechnology/Materials, Molecular biochemistry
Research Interests
Ion channels, Bioorganic chemistry, Pesticide science, 構造生理学, Structural Biology
Published Papers
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The functional impact of mutations in orthosteric binding site of the Drosophila melanogaster Dα2-containing nicotinic receptors points to a greater contribution to neonicotinoid selectivity of an arginine in loop D of Dβ1 than an introduced serine in loop C of Dα2
Ryo Ito; Hisanori Ojima; Miyu Takeuchi; Hiyori Takahashi; Makoto Ihara; David B. Sattelle; Kazuhiko Matsuda
Insect Biochemistry and Molecular Biology 183 , 104380-104380, Sep. 2025 -
Molecular arrangements that accompany binding of rice xylanase inhibitor protein OsXIP and the Rhizopus oryzae GH11 xylanase RXyn2
Takayuki Ohnuma; Jun Tanaka; Harutada Ozaki; Keigo Mitsui; Daichi Tsujitsugu; Miki Okugawa; Toru Takeda; Makoto Ihara; Tamo Fukamizo; Daijiro Takeshita
Journal of Biological Chemistry Aug. 2025 -
Synthesis and Structure–Activity Relationship of Phosphonate Esters with (S)-Cinerolone and (S)-Jasmololone as Irreversible Inhibitors of the GDSL Esterase/Lipase TcGLIP to Study Pyrethrin Biosynthesis
Takato Kurosawa; Noritada Matsuo; Keisuke Takemoto; Akari Murai; Makoto Ihara; Yoo Tanabe; Kazuhiko Matsuda
ACS Omega 20, May. 2025
Conference Activities & Talks
- セイヨウミツバチのニコチン性アセチルコリン受容体の機能的発現と薬理特性に対する補助因子の効果 , 伊原 誠; 高山 浩一; 伊藤 稜; 森 澄海人; 武林 真由花; 江川 瑠夏; 山本 新菜; 木村 裕紀; 松田 一彦 , 日本農芸化学会2024年度大会 , 25, Mar. 2024
- Paraherquamide A の C. elegans ニコチン性アセチルコリン受容体サブタイプ選 択性の分子機構 , 伊原誠; 大坪柊也; 高山浩一; 松田一彦 , 2023 年度 日本農芸化学会 中部・関西支部合同大会 （中部支部：第 196 回例会）（関西支部：第 527 回講演会） , 1, Oct. 2023
- Determinants of sub-type selectivity of Paraherquamide A on Caenorhabditis elegans nicotinic acetylcholine receptors , Makoto Ihara , Control of Human Disease Vectors, Pests and Parasites , Sep. 2023
MISC
- Structure-activity relationship of perhydrohistrionicotoxins for inhibition of the α4β2 nicotinic acetylcholine receptor , 森澄海人; 西川慶祐; 小野陽介; 高山浩一; 伊原誠; 松田一彦; 森本善樹 , 日本農薬学会大会講演要旨集(CD-ROM) , 49th , 2024
- Effects of the cofactors on the functional expression and the pharmacology of honeybee nicotinic acetylcholine receptors , 伊原誠; 高山浩一; 伊藤稜; 森澄海人; 武林真由花; 江川瑠夏; 山本新菜; 木村裕紀; 松田一彦 , 日本農芸化学会大会講演要旨集(Web) , 2024 , 2024
- Roles of the Drosophila melanogaster Dα4 and Dβ3 subunits in their interactions with neonicotinoids , 高山浩一; 小森勇磨; 伊原誠; SATTELLE David B.; 松田一彦 , 日本農芸化学会大会講演要旨集(Web) , 2024 , 2024
Awards & Honors
- Mar. 2018, 日本農芸化学会, 農芸化学奨励賞
- 2008, 日本農学進歩賞
- 2007, 望月喜多司記念賞 奨励賞
Research Grants & Projects
- 日本学術振興会, 科学研究費助成事業, 選択的害虫防除に向けた種選択能を有したニコチン性受容体標的薬剤設計の分子基盤研究 , 近畿大学
- 日本学術振興会, 科学研究費助成事業 基盤研究(B), 選択的害虫防除に向けた種選択能を有したニコチン性受容体標的薬剤設計の分子基盤研究 , 近畿大学
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Elucidation of the molecular determinants of neonicotinoid toxicity , Kindai University