Researchers

HIRAKI Yoko

HIRAKI Yoko
Lecturer in Medical School
Faculty Department of Medicine
Researchmap https://researchmap.jp/hiraki.y

Research Activities

Research Areas

  • Other, Other

Published Papers

  1. Surgical tips and tricks for laparoscopic intragastric surgery for submucosal tumors relative to the esophagogastric junction.
    Atsushi Yasuda; Yutaka Kimura; Hiroaki Kato; Tomoya Nakanishi; Masashi Koda; Yoko Hiraki; Takaomi Hagi; Osamu Shiraishi; Masayuki Shinkai; Motohiro Imano; Takushi Yasuda
    Updates in surgery  13, Jan. 2024 
  2. Efficacy of palliative surgery for gastric cancer patients with peritoneal metastasis who still have residual peritoneal dissemination after chemotherapy.
    Masayuki Shinkai; Motohiro Imano; Masashi Kohda; Tomoya Nakanishi; Yoko Hiraki; Takaomi Hagi; Hiroaki Kato; Osamu Shiraishi; Atsushi Yasuda; Masanobu Tsubaki; Shozo Nishida; Takushi Yasuda
    Langenbeck's archives of surgery  408  (1)  , 291-291, 31, Jul. 2023 
  3. Impact of Relative Dose Intensity of Docetaxel, Cisplatin, and 5-Fluorouracil Neoadjuvant Chemotherapy on Survival of Esophageal Squamous Cell Cancer Patients.
    Osamu Shiraishi; Hiroaki Kato; Kota Momose; Yoko Hiraki; Atsushi Yasuda; Masayuki Shinkai; Motohiro Imano; Takushi Yasuda
    Oncology  101  (3)  , 203-212, 2023 

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MISC

  1. 腎機能低下を伴う進行食道癌患者に対する安全な3剤併用術前化学療法(UDON療法) , 木村 豊; 白石 治; 岩間 密; 加藤 寛章; 川上 尚人; 奥野 達哉; 平木 洋子; 安田 篤; 新海 政幸; 今野 元博; 中川 和彦; 安田 卓司 , 癌と化学療法 , 46 , 13 , 2173 , 2175 , Dec. 2019
    Summary:腎機能低下を伴う進行食道癌に対して術前化学療法(NAC)として5-FU+DTX+nedaplatin(NED)(UDON)療法を施行し、その有用性をretrospectiveに検討した。クレアチニン・クリアランス(Ccr)が50mL/min未満の進行食道癌5例を対象として、NACとしてUDON療法[5-FU640mg/m2(day1〜5)、NED72mg/m2(day1)、DTX28mg/m2(day1、15)、休薬2週間を1コース]を2コース施行した後に根治手術を施行した。化学療法の有害事象(AE)を評価し、臨床的な効果について検討した。患者背景は、男性4例、女性1例、年齢の中央値(範囲)79(58〜80)歳、performance status(PS)1:3、PS2:2例であった。腫瘍の主占居部位は、Ce 1、Ut 1、Mt 3例、進行度はcStage IIA1、IIIA2、IIIC2例であった。grade(Gr)3以上のAEは、好中球減少、低Na血症がそれぞれ2例、発熱性好中球減少、下痢がそれぞれ1例であった。抗腫瘍効果は部分奏効4例、安定1例、組織学的効果は、Gr 1a:Gr 1b=2:3であった。腎機能低下のため高用量CDDP投与が困難な進行食道癌患者に対するNACとして、UDON療法は有用である。(著者抄録)
  2. [A Case of Intestinal Perforation Due to a Catheter for Intraperitoneal Access Port for Intraperitoneal Chemotherapy for Gastric Cancer]. , Yoko Hiraki; Yutaka Kimura; Motohiro Imano; Atsushi Yasuda; Hiroaki Kato; Mitsuru Iwama; Osamu Shiraishi; Masayuki Shinkai; Haruhiko Imamoto; Hiroshi Furukawa; Takushi Yasuda , Gan to kagaku ryoho. Cancer & chemotherapy , 45 , 13 , 2381 , 2383 , Dec. 2018
    Summary:The usefulness of intraperitoneal(IP)chemotherapy for gastric cancer with intraperitoneal metastasis has been examined in some clinical trials. We report a case of intestinal perforation caused by a catheter for IP ports. A 75-year-old man had undergone IP therapy for type 4 gastric cancer. After IP therapy, he underwent total gastrectomy. He had no recurrence for 3 years. He complained of high fever and abdominal pain more than 1 week ago. Based on contrast-enhanced CT, we diagnosed him with peritonitis by intestinal perforation due to the catheter, and on the same day, we removed the catheter and performed intraperitoneal drainage by emergent laparotomy. The tube penetrated the ileum 20 cm from the ileocecal portion. We resected the ileocecal area and damaged intestinal tract and removed the subcutaneous IP port. He was discharged on the 25th postoperative day. IP ports should be removed after the completion of IP chemotherapy because the incidence of perforation by IP ports was reported as 0 to 3.5%in a previous report.
  3. [A Case Report on Successful Larynx-Preserving Surgery for a Cervical Esophageal Cancer That Invaded the Hypopharynx]. , Osamu Shiraishi; Hiroaki Kato; Mitsuru Iwama; Yoko Hiraki; Atsushi Yasuda; Masayuki Shinkai; Motohiro Imano; Yutaka Kimura; Haruhiko Imamoto; Takushi Yasuda , Gan to kagaku ryoho. Cancer & chemotherapy , 44 , 12 , 1844 , 1846 , Nov. 2017
    Summary:The patient was a 58-year-old man suffering from dysphagia. He was diagnosed with T3 cervicalesophagealcancer that invaded the posterior hypopharyngealwal lwith lymph node metastasis. The patient received neoadjuvant chemoradiotherapy (30 Gy with CDDP/5-FU), followed by larynx-preserving surgery(LPS)for cervicalesophagealcancer. Two techniques for successfulLPS consist of the dissections of cricopharyngealmuscl e and the inferior pharyngealsphincter, and the complete division of the bilateral infrahyoid muscles attached to the sternum(CDBIMS). The former technique of releasing the esophagus from the trachea at the cricoid cartilage level results in the extension of the oral surgical margin. The latter technique is expected to prevent postoperative aspiration pneumonia, as the lack of flexibility of scarred infrahyoid muscles is regarded as one of the major causes of dysfunction in swallowing. Free jejunum was transferred for cervical reconstruction. Pathological examination indicated degenerated squamous cell carcinoma(ypT2, INF b, ly0, v0, PM0, ypN0, ypStage II A). Although the patient had recurrent nerve palsy, he could eat meals without aspiration. He returned to normal life after discharge from the hospital. Five years after surgery, no recurrence had been observed.

Research Grants & Projects

  1. 日本学術振興会, 科学研究費助成事業, 薬物介入による血中サブスタンスP濃度制御と食道癌術後の誤嚥治療または予防効果 , 近畿大学
  2. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Dissemination of free cancer cells during esophageal cancer surgery , Kindai University
  3. Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Usefulness of plasma substance P concentration as a predictive factor for aspiration after esophagectomy , Kindai University