Pharmaceutical Analytical

Research Project

1）

Development of the various methods for the comprehensive analysis of glycoprotein glycans.

2）

Affinity capillary electrophoresis using lectins and glycosidases for profiling of glycoprotein glycans.

3）

In situ photopolymerization of polyacrylamide gels for the permselective preconcentration of anions, and protein-impregnated gel for specific entrapment.

4）

Development of extra-sensitive (>100 000 times) sample preconcentration methods for capillary electrophoresis and microchip electrophoresis.

5）

Determination of blood concentration of anticancer drugs for pharmacokinetic study.

Introduction

We believe “the development of analytical methods promotes the progress of science.”To demonstrate our vision, we undertake top-down and bottom-up approaches for developing unique analytical methods.
Our top-down approach focuses on developing several methods including: (1) specific entrapment of glycans, lectin and glycosidase affinity capillary electrophoresis, and (2) labeling of various fluorimetric glycoprotein glycans (Project #1 and #2).
Our bottom-up approach is related to the applicaton of polymer science to microchip capillary electrophoresis.
(Project #3 and #4).
This course enables you to pursue a career in the instrumental analysis and quality control section in the pharmaceutical industry or in public services.
You will learn background knowledge based on the analytical technique theory used in pharmaceutical science, which will enable you to solve complex problems in your future.
In addition to studying core analytical techniques and their applications, you will be introduced to various pharmaceutical technologies, for example, solid phase extraction of pharmaceuticals in blood and their analysis using LC/MS for clinical pharmacokinetic studies (Project #5).