Pharmacology and Pathophysiology
Research Project
Study on the molecular functions and pathophysiology of hydrogen sulfide (H2S), an endogenous gasotransmitter
Drug development research targeting T-type calcium channels
Study on high mobility group box 1 (HMGB1), a nuclear protein, as a target for drug development
Advanced study of drug development targeting proteinase-activated receptors (PARs)
Neuropharmacological study on the molecular mechanisms for pain signal transduction for development of novel analgesics
Introduction
In collaboration with some pharmaceutical companies, we are also studying the impact of high mobility group box (HMGB1), a nuclear protein, prostaglandins, vitamin C or proteinase-activated receptors (PARs) on intractable and persistent pain, gastrointestinal diseases or cancer for the development of novel therapeutic agents.
We thus analyze the functions and roles of specific endogenous molecules at gene, protein, cell, tissue and whole-body levels as they relate to the practical application of our research findings for the development of novel therapeutic strategies.