Biopharmaceutics

Research Project

Effects of pathological conditions on the expression and function of metabolic enzymes and transporters
Roles of metabolic enzymes and transporters in induction of idiosyncratic hepatic toxicity
Stereoselective recognition of metabolic enzymes and transporters
Prediction of in vivo metabolic activity using the in vitro-in vivo extrapolation approach
Overcoming cancer multidrug resistance for improving drug delivery to tumor cells

Introduction

Biopharmaceutics is a study involving pharmacokinetics (the kinetics of absorption, distribution, metabolism, and excretion of drugs), pharmacodynamics and drug metabolism using basic, translational and clinical science research methods.
Biopharmaceutics also provides effective educational and training experiences for professional (department of pharmacy) and undergraduate (department of pharmaceutical sciences) students and graduate (MS, PhD) students in the areas of bioanalysis, pharmacokinetics/pharmacodynamics, pharmacogenomics, drug transport and metabolism.
We investigate pharmacokinetics in pathological conditions and the physiological factors (CYP450, transporters and nuclear receptors) involved in altered drug metabolism and disposition.
We also pursue the goal of contributing to finding the optimal drug therapies for human clinical use.
Recently, our research has focused on; 1) prediction of pharmacokinetics based on in vitro metabolic studies, 2) mechanisms of altered pharmacokinetics in chronic inflammatory conditions using model animals, and 3) effect of nuclear receptors on drug disposition in physiological conditions.